J. Gu

Morphometric analysis of actin networks

This study benchmarks morphometric parameters for actin networks using synthetic data and applies them to Arabidopsis root epidermal cells to detect subtle organizational changes.

Respiratory mucosal administration of DNA aptamer nanomaterials protects against antigenically diverse SARS-CoV-2 variants

This study shows that DNA aptamer nanomaterials can protect against diverse SARS-CoV-2 variants through respiratory mucosal administration, offering broad neutralization and superior protection compared to monoclonal antibodies.

Intestinal commensal bacteria promote Bactrocera dorsalis larval development through vitamin B6 synthesis pathway

This study identifies vitamin B6 synthesis by intestinal bacteria as critical for promoting Bactrocera dorsalis larval growth under poor diet conditions.

N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

This study shows that N-acetylation of α-synuclein enhances its ability to cluster synaptic vesicles via increased interaction with lysophosphatidylcholine.

Ubiquitin-mediated stabilization of SlPsbS regulates low night temperature tolerance in tomatoes

This study identifies a ubiquitin-mediated degradation pathway involving SlCV and SlCSN5A that regulates SlPsbS stability under low night temperatures in tomatoes.

HCCDB v2.0: Decompose the Expression Variations by Single-cell RNA-seq and Spatial Transcriptomics in HCC

HCCDB v2.0 integrates bulk, single-cell, and spatial transcriptomic data from HCC samples to enhance meta-analysis and provide new metrics for gene expression patterns.

Deciphering the co-evolutionary dynamics of L2 β-lactamases via Deep learning

This paper uses deep learning to analyze the co-evolutionary dynamics of L2 β-lactamases and their functional mechanisms.

Oxidative regulation of TDP-43 self-association by a beta-to-alpha conformational switch

This paper shows that oxidative modification of TDP-43's low complexity domain induces a beta-to-alpha conformational switch, disrupting self-association and phase separation.

An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytes

The paper identifies an unconventional IL-1β secretion mechanism in lupus monocytes requiring Type I IFN, involving mitochondrial RNA and the NLRP3 inflammasome.

Host-microbiota interactions contributing to the heterogeneous tumor microenvironment in colorectal cancer

The paper identifies host-microbiota interactions in colorectal cancer subtypes, revealing distinct gene-microbe associations that contribute to tumor microenvironment heterogeneity.

The Structural Role of N170 in Substrate-assisted Deacylation in KPC-2 β-Lactamase

This study investigates the structural role of N170 in substrate-assisted deacylation in KPC-2 β-lactamase, revealing its impact on drug binding and catalytic activity.

Duplications of human longevity-associated genes across placental mammals

This study investigates the link between gene duplication and mammalian longevity by analyzing 287 human longevity-associated genes across 37 placental mammals, finding that duplication rates are eight times higher than contraction rates and identifying 43 genes significantly correlated with longevity.

Development of a xylose-inducible promoter and riboswitch combination system for manipulating gene expression in Fusobacterium nucleatum

This paper develops a leakage-free gene expression system in Fusobacterium nucleatum by combining a xylose-inducible promoter with a theophylline-responsive riboswitch, demonstrating precise control of gene expression and identifying essential genes.

Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase

The paper investigates how gating interactions between loops in the L1 metallo-β-lactamase affect active site conformational changes and identifies key residues critical for enzyme activity.

Dual control of lysogeny and phage defense by a phosphorylation-based toxin/antitoxin system

This paper identifies a phosphorylation-based toxin/antitoxin system in Pseudomonas aeruginosa that regulates prophage activation and defends against lytic phages.

Telomere dysfunction impairs intestinal differentiation andpredisposes to diet-induced colitis

This study shows that telomere shortening impairs intestinal differentiation, leading to barrier defects and diet-induced colitis through microbiome modulation and nutrient flux.

The radio-protective effects of (-)-Epigallocatechin-3-gallate (EGCG): regulating macrophage function in radiation-induced intestinal injury.

This study shows EGCG protects against radiation-induced intestinal injury by preserving macrophages and gut microbiota, reducing inflammation and improving survival in mice.

Generating Functional Cells Through Enhanced Interspecies Chimerism with Human Pluripotent Stem Cells

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

Differential UBE2H-CTLH E2-E3 ubiquitylation modules regulate erythroid maturation

The paper identifies UBE2H-CTLH ubiquitylation modules that regulate stages of human erythropoiesis, showing their role in controlling maturation and heme synthesis.

The ulcerative colitis associated gene FUT8 regulates the quantity and quality of secreted mucins

This study shows that FUT8 regulates mucin secretion and viscoelastic properties, linking its dysfunction to ulcerative colitis pathogenesis.

Heat shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition

This study shows HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition, with implications for neurodegenerative diseases like ALS.

A vimentin-targeting oral compound with host-directed antiviral and anti-inflammatory actions addresses multiple features of COVID-19 and related diseases

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.

A novel non-antibiotic selectable marker GASA6 for plant transformation

This paper identifies GASA6 as a non-antibiotic selectable marker for plant transformation, demonstrating its effectiveness in tobacco through growth and regeneration on sugar-free media.

Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis

This paper introduces MOSAICA, a spatial transcriptomics technology that combines spectral and lifetime encoding with machine learning to enable highly multiplexed in situ biomarker profiling.

Comprehensive Analysis of Spatial Architecture in Primary Liver Cancer

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

Vaccination-induced rapid protection against bacterial pneumonia via training alveolar macrophage in mice

This study shows a single intranasal vaccination with inactivated Acinetobacter baumannii rapidly protects mice against pneumonia by training alveolar macrophages, with effects observed against other Gram-negative bacteria but not Gram-positive ones.

Combined oncolytic adenovirus carrying MnSOD and mK5 genes both regulated by survivin promoter has synergistic inhibitory effect on gastric cancer

This study constructs two oncolytic adenoviruses carrying mK5 or MnSOD genes under survivin promoter control and shows their combined use significantly inhibits gastric cancer growth in vitro and in vivo.

The nonstructural protein 5 of coronaviruses antagonizes GSDMD-mediated pyroptosis by cleaving and inactivating its pore-forming p30 fragment

This study identifies how coronavirus Nsp5 protein inhibits pyroptosis by cleaving GSDMD, preventing pore formation and viral replication inhibition.

Hsp70 chaperons TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation

This study shows Hsp70 chaperones TDP-43 in liquid-like phase, preventing its aggregation and maintaining dynamic nuclear bodies under stress.

exosome-LncPICALM-AU1 regulates endothelial-mesenchymal transition in hepatopulmonary syndrome

This study identifies exosomal lncRNA PICALM-AU1 from cholangiocytes as a key regulator of endothelial-mesenchymal transition in hepatopulmonary syndrome, with potential as a biomarker and therapeutic target.