Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.
M. Di Gioia, V. Poli, P. Tan, R. Spreafico, A. Chou, A. Cuenca, P. Gordts, L. Pandolfi, F. Meloni, J. Witztum, J. Chou, J. Springstead, I. Zanoni
The paper shows host-derived oxidized phospholipids initiate effector-triggered immunity, leading to lethality upon microbial encounter, and demonstrates that blocking oxPLs reduces inflammation and host death.
bioRxiv · Nov 21, 2023 · PreprintImmunology