Uncovering Minimal Pathways in Melanoma Initiation
H. Xiao, J. Shiu, C.-F. Chen, J. Wu, P. Zhou, S. S. Telang, R. Ruiz-Vega, A. D. Lander, A. K. Ganesan
This study identifies LNM cells as a pre-malignant state in melanoma initiation, showing they pre-exist in normal skin, expand with Braf activation, and contribute to drug resistance.
bioRxiv · Dec 8, 2023Cancer Biology