Author

K. Le

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Assay:CITE-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. Sok· 2 shared A. Calof· 1 shared A. D. Lander· 1 shared A. Gonzalez-Martin· 1 shared A. J. Feeney· 1 shared A. J. Smith· 1 shared A. Liguori· 1 shared A. Palser· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersImmunology

D. Sok

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC

X. Yuan, X. Hao, H. L. Chan, N. Zhao, D. A. Pedroza, F. Liu, K. Le, A. J. Smith, S. J. Calderon, N. Lieu, M. J. Soth, P. Jones, X. H.- F. Zhang, J. M. Rosen

CBP/P300 BRD inhibition reduces neutrophil accumulation and enhances antitumor immunity in neutrophil-enriched TNBC, improving responses to standard therapies.

bioRxiv · Apr 25, 2024 · PreprintCancer Biology

Diverse competitor B cell responses to a germline-targeting priming immunogen in human Ig loci transgenic mice

T. Schiffner, A. Palser, J. G. Jardine, A. Liguori, S. Menis, S. Raemisch, X. Hu, D. W. Kulp, X. Wang, J. K. Diedrich, B. Groschel, O. Kalyuzhniy, R. Tingle, K. Le, E. Georgeson, , W. R. Schief

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.

bioRxiv · Jan 22, 2024 · PreprintImmunology

Deep learning for robust and flexible tracking in behavioral studies for C. elegans

H. Lu, K. Bates, K. Le

This paper applies Faster R-CNN to track C. elegans behavior across different life stages and conditions, demonstrating its flexibility and scalability for large-scale studies.

bioRxiv · Feb 8, 2021Bioengineering

NTR 2.0: a rationally-engineered prodrug converting enzyme with substantially enhanced efficacy for targeted cell ablation

A. v. Sharrock, T. S. Mulligan, K. R. Hall, E. M. Williams, D. T. White, L. Zhang, F. Matthews, S. Nimmagadda, S. Washington, K. Le, D. Meir-Levi, O. L. Cox, M. T. Saxena, A. Calof, M. E. Lopez-Burks, , J. S. Mumm

This paper describes the development of NTR 2.0, a modified nitroreductase with significantly improved efficacy for targeted cell ablation using metronidazole.

bioRxiv · May 22, 2020Cell Biology

Reprogramming the antigen specificity of B cells using genome-editing technologies

J. E. Voss, A. Gonzalez-Martin, R. Andrabi, R. P. Fuller, B. Murrell, L. E. McCoy, K. Porter, D. Huang, W. Li, D. Sok, K. Le, B. Briney, M. Chateau, G. Rogers, L. Hangartner, , D. Burton

This study reprograms B cells to express HIV-specific BCRs by editing immunoglobulin genes with CRISPR-Cas9, enabling improved anti-HIV neutralizing activity.

bioRxiv · Oct 29, 2018Immunology