Identification of a Novel Ferroptosis Inducer with Dual Modulatory Effects on GPX4 Activity and Stability
J. Wang, L. Liao, B. Yang, B. Miao, B. Li, X. Ma, A. Fitz, S. Wu, J. He, Q. Zhang, S. Ji, G. Jin, J. Zhang, R. Bernards, W. Qin, , C. Wang
This study identifies MI-2, a novel GPX4 inhibitor that induces ferroptosis by inhibiting GPX4 activity and promoting its degradation, showing synergistic effects with existing cancer drugs.
bioRxiv · Dec 22, 2023 · PreprintCell Biology