S. A. Ware

Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging

The paper shows chronic glucocorticoid exposure increases cellular energy expenditure and accelerates aging in human fibroblasts.

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues

This study shows that mitochondrial dysfunction triggers a retrograde signaling program that reduces cellular maturity in metabolic tissues, and blocking this signaling can restore cell identity and improve hyperglycemia.

A Multi-Omics and Bioenergetics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations

The paper presents a longitudinal multi-omics dataset of human fibroblasts with mitochondrial perturbations to study aging mechanisms and bioenergetics.

Extracellular release of mitochondrial DNA is triggered by cigarette smoke and is detected in COPD

This study shows that cigarette smoke triggers mitochondrial DNA release in COPD patients and animal models, linking it to inflammation and disease progression.

An automated, high throughput methodology optimized for quantitative cell-free mitochondrial and nuclear DNA isolation from plasma

The paper optimizes an automated high-throughput method for isolating cell-free mitochondrial and nuclear DNA from plasma, achieving 6-fold higher yields of mitochondrial DNA.