Q. Yan

Unicellular cyanobacteria rely on sodium energetics to fix N2

This study shows that unicellular cyanobacteria rely on sodium energetics for N2 fixation, which may explain their low abundance in coastal waters due to insufficient NaCl levels.

MaUGT79 confers drought tolerance by regulating scopolin biosynthesis in plants

This study identifies MaUGT79 as a gene regulating scopolin biosynthesis, which enhances drought tolerance in plants through ROS scavenging and transcriptional activation by MaMYB4.

Epigenetic predictors of species maximum lifespan and other life history traits in mammals

The paper develops DNA methylation predictors for mammalian maximum lifespan, gestation time, and sexual maturity, showing species-level epigenetic signatures that differ from individual lifespan variation.

Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein driving the genesis of Omicron variants

The paper identifies public antibodies using VL6-57 light chains that target a conserved epitope on SARS-CoV-2 spike protein, showing how Omicron variants evolved to escape these antibodies.

Disease-associated gut microbiome and metabolome changes in chronic low back pain patients with bone marrow lesions

This study examines gut microbiome and serum metabolome changes in chronic low back pain patients with bone marrow lesions, identifying key microbial species and metabolic pathways involved.

A Gpr35 tuned gut-brain metabolic axis regulates depressive-like behavior

This study identifies Gpr35 as a regulator of a gut-brain metabolic axis that influences depressive-like behavior in mice, highlighting microbial metabolites as potential therapeutic targets.

MicroRNA-29 Differentially Mediates Preeclampsia-Dysregulated Cellular Responses to Cytokines in Female and Male Fetal Endothelial Cells

This study identifies miR-29a/c-3p dysregulation in PE as sex-specific modulator of cytokine responses in fetal endothelial cells, with distinct effects on monolayer integrity and proliferation.

Epithelial galectin-3 induces mitochondrial complex inhibition and cell cycle arrest of CD8+ T Cells in severe/critical ill COVID-19

This study identifies galectin-3 as a factor that inhibits mitochondrial function and causes cell cycle arrest in CD8+ T cells of severe/critical COVID-19 patients, with potential therapeutic implications.

Dopamine promotes Klebsiella quasivariicola proliferation and inflammatory response in the presence of macrophages

This study shows dopamine promotes Klebsiella quasivariicola growth and inflammation in macrophage co-culture, exacerbating lung injury in mice.

Cataloguing and profiling of the gut virome in Chinese populations uncover extensive viral signatures across common diseases

The paper catalogs and profiles the gut virome in Chinese populations, identifying novel viruses and disease-associated viral signatures.

Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses

This study shows DYRK1A promotes viral entry of SARS-CoV, SARS-CoV-2, and MERS-CoV by regulating ACE2 and DPP4 transcription without its kinase activity.

Meta-analysis of fecal metagenomes reveals global viral signatures and its diagnostic potential for colorectal cancer and adenoma

This study analyzes fecal metagenomes to identify viral signatures associated with colorectal cancer and adenoma, finding distinct virome patterns and developing predictive models with high accuracy.

WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

This study identifies WDR5 as an epigenetic regulator that promotes breast cancer growth and metastasis through KMT2-independent translation regulation, suggesting therapeutic strategies targeting WDR5.

SLDP and LIPA mediate lipid droplet-plasma membrane tethering in Arabidopsis thaliana

SLDP1, SLDP2, and LIPA tether lipid droplets to the plasma membrane in Arabidopsis thaliana seedlings.

Single-cell transcriptome profiling reveals multicellular ecosystem of nucleus pulposus during degeneration progression

This study uses single-cell transcriptomics to identify novel cell populations and functional differences in human nucleus pulposus during degeneration, revealing potential regenerative and immunosuppressive roles.

Integrative molecular and clinical profiling of acral melanoma identifies LZTR1 as a key tumor promoter and therapeutic target

A polyyne toxin produced by an antagonistic bacterium blinds and lyses a green microalga

This study identifies a polyyne toxin produced by Pseudomonas protegens that blinds and lyses Chlamydomonas reinhardtii by targeting its eyespot, alongside orfamide A, to disrupt phototaxis.

Dysbiotic oral and gut viromes in untreated and treated rheumatoid arthritis patients

This study analyzes oral and gut viromes in RA patients and controls to explore their potential role in RA development.

Genome-wide screen of genomic imprinting in endosperm and population-level analysis reveal allelic variation for imprinting in flax

The paper identifies imprinted genes in flax endosperm and shows their role in intraspecific variation and domestication.

A Proteomic Platform to Identify Off-Target Proteins Associated with Therapeutic Modalities that Induce Protein Degradation or Gene Silencing

The paper develops a proteomics platform to identify off-target proteins affected by PROTAC and RNAi therapies, using a selected off-target proteome and LC-MS/MS quantification.

KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma

This study shows KDM2B promotes canine hemangiosarcoma cell viability by enhancing DNA damage response and suggests GSK-J4 as a potential therapeutic alternative.

CECR2 Drives Breast Cancer Metastasis by Suppressing Macrophage Inflammatory Responses

This study identifies CECR2 as a driver of breast cancer metastasis by suppressing macrophage inflammatory responses, offering a therapeutic target for metastatic disease.

Micro-XRF study of the troodontid dinosaur Jianianhualong tengi reveals new biological and taphonomical signals

This study uses micro-XRF to analyze the holotype of Jianianhualong tengi, revealing elemental patterns linked to fossil structure and taphonomy.

Cellular aging in vitro recapitulates multi-tissue epigenetic aging in vivo

This study shows that in vitro cellular aging models can reflect multi-tissue epigenetic aging in vivo, using DNAmCULTURE as a measure that tracks aging across tissues and responds to interventions.

SARS-CoV-2 manipulates the SR-B1-mediated HDL uptake pathway for its entry

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

Characterization of the gut DNA and RNA viromes in a cohort of Chinese residents and visiting Pakistanis

This study compares the gut DNA and RNA viromes of Chinese residents and Pakistani visitors, finding ethnic origin significantly influences virome composition and diversity.

Functional requirement of the Arabidopsis importin-α nuclear transport receptor family in autoimmunity mediated by the NLR protein SNC1

The paper identifies IMP-3/MOS6 as the main nuclear transport receptor for SNC1, showing its specific requirement for autoimmunity and basal resistance in Arabidopsis.

Analysis of metagenome-assembled genomes from the mouse gut microbiota reveals distinctive strain-level characteristics

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.

Aging immune system-related blood cell DNA methylation can predict the onset of early stage colorectal cancer

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.