A. Jacobs

Standardization of suspension and imaging mass cytometry readouts for clinical decision making

This study standardizes suspension and imaging mass cytometry measurements to improve clinical reproducibility and provide oncologists with tumor biology insights.

Rapid intralacustrine evolution of an invasive pelagic three-spined stickleback (Gasterosteus aculeatus) ecotype in Lake Constance.

This study investigates the origin and genomic basis of a rapidly evolving pelagic stickleback ecotype in Lake Constance, finding it arose from the littoral population with genomic and phenotypic differentiation.

Cell specialization in cyanobacterial biofilm development revealed by expression of a cell-surface and extracellular matrix protein

The paper identifies cell specialization in Synechococcus elongatus biofilm formation, showing a subset of cells produce matrix proteins while others are assembled in the biofilm.

Temperature-dependent gene regulatory divergence underlies local adaptation with gene flow in the Atlantic silverside

This study examines gene regulatory divergence in Atlantic silversides under temperature variation and gene flow, finding trans-regulatory divergence and reduced thermal plasticity in hybrids.

Comparative linkage mapping uncovers massive chromosomal inversions that suppress recombination between locally adapted fish populations

The paper compares recombination landscapes between two Atlantic silverside populations, identifying chromosomal inversions that suppress recombination and impact adaptation.

PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

This study shows that activating PPARD signaling enhances metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

Mass Cytometric and Transcriptomic Profiling of Epithelial-Mesenchymal Transitions in Human Mammary Cell Lines

The paper profiles EMT transition phenotypes in human mammary cell lines using mass cytometry and transcriptomics to understand phenotypic diversity across time and cell lines.

Induction of specific antibodies, IgG-secreting plasmablasts and memory B cells following BCG vaccination

This study investigates the BCG vaccine's induction of specific antibodies, IgG-secreting plasmablasts, and memory B cells in humans and macaques, highlighting the potential role of humoral immunity in TB vaccine development.

Single-Cell Proteomics Defines the Cellular Heterogeneity of Localized Prostate Cancer

This study uses single-cell proteomics to identify cellular heterogeneity in localized prostate cancer and discovers rare subpopulations associated with advanced disease.

A distinct innate immune signature marks progression from mild to severe COVID-19

The paper identifies an innate immune signature associated with progression from mild to severe COVID-19 using mass cytometry and proteomics.

Lymphopenia-induced T cell proliferation is a hallmark of severe COVID-19

This study identifies T cell apoptosis and migration as mechanisms of peripheral T cell lymphopenia in severe COVID-19 and links lymphopenia to subsequent T cell proliferation.

A Phelipanche ramosa KAI2 Protein Perceives enzymatically Strigolactones and Isothiocyanates

This study identifies PrKAI2d3 as a receptor in Phelipanche ramosa that perceives both strigolactones and isothiocyanates, showing its enzymatic activity enhances sensitivity to these signals.

Alternative splicing and gene expression play contrasting roles in the parallel phenotypic evolution of a salmonid fish

The paper compares alternative splicing and gene expression in Arctic charr ecotypes to show they contribute to different aspects of phenotypic divergence.

Repeated genomic signatures of adaptation to urbanisation in a songbird across Europe

The paper identifies repeated genetic adaptations to urbanisation in great tits across Europe, showing polygenic responses and selective sweeps in genes related to neural function.

Convergence in form and function overcomes non-parallel evolutionary histories in a Holarctic fish

This study shows that parallel phenotypic evolution can occur through non-parallel genetic pathways in Arctic charr, with gene expression playing a key role in phenotypic similarity.

Genetic fingerprinting of salmon louse (Lepeophtheirus salmonis) populations in the North-East Atlantic using a random forest classification approach

This study uses IIb-RAD sequencing and random forest algorithms to identify SNPs for fine-scale discrimination of Lepeophtheirus salmonis populations in the North-East Atlantic.