C. Fankhauser

Pectin methylesterification modulates cell wall properties to promote neighbour proximity-induced hypocotyl growth

The study shows that pectin methylesterification modulates cell wall properties to enable neighbor proximity-induced hypocotyl growth in Arabidopsis.

Proteomic-based stratification of intermediate-risk prostate cancer patients

The paper identifies an 18-protein signature from proteomic data to stratify intermediate-risk prostate cancer patients into low- and high-risk groups for biochemical recurrence.

Air channels create a directional light signal to regulate hypocotyl phototropism

The paper shows that air channels in Arabidopsis hypocotyls enhance light scattering, creating a gradient that regulates phototropism through auxin distribution.

Reduced light access promotes hypocotyl growth via autophagy-mediated recycling

This study shows that reduced light and LRFR promote hypocotyl growth through distinct metabolic pathways: autophagy-mediated recycling and plasma membrane lipid biosynthesis.

Control of PHYTOCHROME KINASE SUBSTRATE subcellular localization and biological activity by protein S-acylation

This study identifies S-acylation of PKS4 motif C as critical for its plasma membrane association and biological activity in light-regulated growth responses.

Abscisic Acid modulates neighbor proximity-induced leaf hyponasty in Arabidopsis

This study shows ABA biosynthesis and signaling are required to promote leaf hyponasty in response to a drop in the red to far-red ratio.

Shade suppresses wound-induced leaf repositioning through a mechanism involving PHYTOCHROME KINASE SUBSTRATE (PKS) genes

This study shows that shade suppresses wound-induced leaf repositioning in Arabidopsis through PKS genes, which integrate shade and wounding signals.

Phototropin-mediated perception of light direction in Arabidopsis leaves regulates blade flattening

The paper shows phototropins perceive light direction in Arabidopsis leaves and control auxin signaling to regulate blade flattening.

Single-Cell Proteomics Defines the Cellular Heterogeneity of Localized Prostate Cancer

This study uses single-cell proteomics to identify cellular heterogeneity in localized prostate cancer and discovers rare subpopulations associated with advanced disease.

In Arabidopsis, low blue light enhances phototropism by releasing cryptochrome 1-mediated inhibition of PIF4 expression

High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.

PIF transcription factors link a neighbor threat cue to accelerated reproduction in Arabidopsis

This study identifies PIF transcription factors as mediators of accelerated reproduction in Arabidopsis in response to neighbor proximity light cues.

Low Rate of Somatic Mutations in a Long-Lived Oak Tree

The paper sequenced two branches of a 234-year-old oak tree and found few somatic mutations, suggesting shoot meristems are mutation-resistant.