Author

S. Sharpe

UK Health Security Agency

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Evolutionary Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:non-human primate· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:proteomics· 1

Frequent Co-Authors

A. White· 2 shared C. Ho· 2 shared D. Harris· 2 shared F. J. Salguero· 2 shared H. E. Humphries· 2 shared K. A. Ryan· 2 shared Y. Hall· 2 shared A. Jacobs· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

A. White

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Human CD1c-autoreactive T cells recognise Mycobacterium tuberculosis-infected antigen-presenting cells and display cytotoxic effector programmes

Matthew Milton, Sahar H. Farag, Diana J. Garay‐Baquero, Jennie Gullick, Kinga Niedobecka, Daniel Burns, Rita Szoke‐Kovacs, Patrick Trimby-Smith, Alex Look, Richard J Stopforth, Marco Lepore, David K. Cole, Laura Denney, Andrew White, S. Sharpe, , Salah Mansour

This study shows CD1c-autoreactive T-cells recognize Mtb-infected APCs, exhibit cytotoxicity, and reduce Mtb burden through CD1c-dependent mechanisms.

bioRxiv · Jun 23, 2026Immunology

Structural studies of a serum amyloid A octamer that is primed to scaffold lipid nanodiscs

A. Nady, S. E. Reichheld, S. Sharpe

This study characterizes the structure of lipid-free SAA octamers and shows their ability to scaffold lipid nanodiscs similar to ApoA-I.

bioRxiv · Dec 8, 2023Biochemistry

Induction of specific antibodies, IgG-secreting plasmablasts and memory B cells following BCG vaccination

J. Bitencourt, M. Wilkie, M. P. Peralta Alvarez, A. Jacobs, D. Wright, S. A. Harris, S. G. Smith, S. Elias, A. White, S. Sharpe, M. K. O'Shea, H. McShane, R. Tanner

This study investigates the BCG vaccine's induction of specific antibodies, IgG-secreting plasmablasts, and memory B cells in humans and macaques, highlighting the potential role of humoral immunity in TB vaccine development.

bioRxiv · Feb 18, 2021 · PreprintImmunology

mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 challenge infection

S. Rauch, K. E. Gooch, Y. Hall, F. J. Salguero, M. J. Dennis, F. V. Gleeson, D. Harris, C. Ho, H. E. Humphries, S. Longet, D. Ngabo, J. Paterson, E. L. Rayner, K. A. Ryan, S. Sharpe, , M. W. Carroll

This study shows that the mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 infection and reduces disease severity.

bioRxiv · Dec 23, 2020 · PreprintImmunology

Immunological and pathological outcomes of SARS-CoV-2 challenge after formalin-inactivated vaccine immunisation of ferrets and rhesus macaques

K. R. Bewley, K. E. R. Gooch, K. M. Thomas, S. R. Longet, N. Wiblin, L. Hunter, K. Chan, P. Brown, R. A. Russell, C. Ho, G. Slack, H. E. Humphries, L. Alden, L. Allen, M. Aram, , M. Carroll

This study evaluates vaccine-enhanced disease in ferrets and rhesus macaques after formalin-inactivated SARS-CoV-2 vaccination, finding mild transient lung pathology but no significant enhancement.

bioRxiv · Dec 21, 2020Pathology

The genomic basis of evolved virus resistance is dependent on environmental resources

K. Roberts, S. Meaden, S. Sharpe, S. Kay, T. Doyle, D. Wilson, L. J. Bartlett, S. Paterson, M. Boots

This study identifies genomic mechanisms of virus resistance in a lepidopteran pest, showing that resistance evolves differently under varying nutritional conditions and is linked to metabolic, immune, or cytoskeleton pathways.

bioRxiv · Jun 11, 2019 · PreprintEvolutionary Biology