A. Jamwal

Heparan sulphate binding controls in vivo half-life of the HpARI protein family

The paper shows that DNA and heparan sulphate binding prolongs the in vivo half-life of HpARI1 and HpARI2 proteins compared to HpARI3.

IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing Type 2 immune responses

The paper identifies three HpARI family members in H. polygyrus bakeri, showing they have distinct effects on IL-33-dependent Type 2 immune responses.

Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI

The paper determines the structure of HpARI bound to mouse IL-33, showing how HpARI blocks IL-33 signaling by competing with its receptor ST2.

Structure of the PfRCR complex which bridges the malaria parasite and erythrocyte during invasion

This paper determines the structure of the PfRCR complex using cryogenic-electron microscopy, revealing its modular architecture and interaction with erythrocyte receptors, which informs vaccine design.

Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes

The paper shows that PfRH5 binds to basigin-containing membrane complexes rather than isolated basigin, and effective antibodies block this interaction to inhibit parasite growth.

Engagement rules that underpin DBL-DARC interactions for ingress of Plasmodium knowlesi and Plasmodium vivax into human erythrocytes

This study provides a structural model of how P. knowlesi and P. vivax DBL proteins interact with human DARC to facilitate red blood cell invasion.