N. Alam

Population growth poses a significant threat to forest ecosystems: a case study from the Hindukush-Himalayas of Pakistan

The paper examines how population growth in Pakistan's Malam Jabba area has accelerated deforestation, using remote sensing and a decay model to predict future trends.

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5

This paper designs a malaria vaccine immunogen using structure-guided methods to present a single epitope from PfRH5, showing improved antibody response in rats compared to PfRH5 alone.

Genome Mining and Discovery of Imiditides, a Novel Family of RiPPs with a Class-defining Aspartimide Modification

This paper discovers a novel family of RiPPs called imiditides through genome mining, revealing 670 BGCs and demonstrating heterologous production of mNmaAM with a unique aspartimide modification.

Structure of the PfRCR complex which bridges the malaria parasite and erythrocyte during invasion

This paper determines the structure of the PfRCR complex using cryogenic-electron microscopy, revealing its modular architecture and interaction with erythrocyte receptors, which informs vaccine design.

Identifying Biomarkers of Retinal Pigment Epithelial Cell Stem Cell-derived RPE Cell Heterogeneity and Transplantation Efficacy

The paper identifies a lncRNA, TREX, as a biomarker predicting in vivo efficacy of RPE cell transplantation and shows its impact on cell integration.

Light-responsive monobodies for dynamic control of customizable protein binding

This paper introduces light-responsive monobodies (OptoMBs) that can reversibly control protein binding affinity, demonstrating their utility in purification and potential for light-switchable applications.