A. Janssen

Protective function of ex vivo expanded CD8 T cells in a mouse model of adoptive therapy for cytomegalovirus infection depends on integrin beta 1 but not CXCR3, CTLA4, or PD-1 expression

DNA density is a better indicator of a nuclear bleb than lamin B loss

The paper compares lamin B and DNA levels in nuclear blebs across cell types and perturbations, finding DNA concentration is more consistently reduced than lamin B levels.

DNA Double-Strand Break Movement in Heterochromatin Depends on the Histone Acetyltransferase dGcn5.

This study shows that dGcn5-mediated H3K9ac enrichment at heterochromatic DSBs is essential for their movement to the periphery and proper repair.

Adult thymus-derived cMaf+ RORγt+ γδ T cells lack Scart2 chromatin accessibility and do not reach periphery

The soybean rust pathogen Phakopsora pachyrhizi displays transposable element proliferation that correlates with broad host-range adaptation on legumes

This study sequenced three Phakopsora pachyrhizi genomes, revealing high transposable element content and its correlation with host-range adaptation in legumes.

Tumor-reactivity of d2 negative gdT cells and the role of the gdT cell receptor

The paper investigates tumor-reactivity of {delta}2 negative {gamma}{delta}T cells and finds that tumor-reactivity is not solely mediated by the {delta}2 negative {gamma}{delta}TCR.

Degree and site of chromosomal instability define its oncogenic potential

This study shows that chromosomal instability (CIN) can drive early-onset intestinal adenomas, with varying effects depending on CIN levels and tissue site.

Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A