K. Robinson

In vivo PSC differentiation as a platform to identify factors for improving the engraftability of cultured muscle stem cells

The paper identifies LIF as a factor that improves the engraftability of cultured muscle stem cells using an in vivo PSC differentiation platform.

'Drifting' Buchnera genomes track the microevolutionary trajectories of their aphid hosts

The paper analyzes Buchnera genome variation across aphid clones to show genetic drift with host evolution, finding no plant host or geographic associations.

Mechanistic basis for nigericin-induced NLRP1 inflammasome activation in human epithelial cells

This study identifies the mechanism by which nigericin activates the NLRP1 inflammasome in human epithelial cells through potassium efflux and ribotoxic stress response.

The soybean rust pathogen Phakopsora pachyrhizi displays transposable element proliferation that correlates with broad host-range adaptation on legumes

This study sequenced three Phakopsora pachyrhizi genomes, revealing high transposable element content and its correlation with host-range adaptation in legumes.

Genomic diversity of Helicobacter pylori populations from different regions of the human stomach.

This study uses whole-genome sequencing to analyze H. pylori genetic diversity within and between stomach regions, revealing extensive allelic diversity and recombination patterns.

Sex-specific distribution and classification of Wolbachia infections and mitochondrial DNA haplogroups in Aedes albopictus from the Indo-Pacific

The paper analyzes genomic data from Aedes albopictus across the Indo-Pacific to classify Wolbachia infections and mitochondrial haplogroups, finding sex-specific infection patterns and no cryptic species.

RAGE antagonist peptide mitigates AGE-mediated endothelial hyperpermeability and accumulation of glycoxidation products in human ascending aortas and in a murine model of aortic aneurysm

Direct cleavage of human NLRP1 by enteroviral 3C protease triggers inflammasome activation in airway epithelium

The paper identifies enteroviral 3C proteases as the first cognate PAMP ligand for human NLRP1, showing they trigger inflammasome activation and airway inflammation.

Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8

This study reveals the structural mechanisms by which NLRP1 and CARD8 assemble distinct inflammasome complexes through unique CARD domain interactions.

Characterization of GRK5 as a novel regulator of rhabdomyosarcoma tumor cell growth and self-renewal

This study identifies GRK5 as a novel regulator of rhabdomyosarcoma growth and self-renewal, showing its kinase-independent role in promoting tumor progression and suggesting it as a therapeutic target.

HDAC6 promotes self-renewal and migration/invasion of rhabdomyosarcoma

This study identifies HDAC6 as a driver of RMS tumor growth, self-renewal, and migration/invasion, with RAC1 as a key mediator, suggesting targeting the HDAC6-RAC1 axis as a therapeutic strategy.

Macronutrients modulate resistance to infection and immunity in Drosophila

This study shows that Drosophila infected with M. luteus reduce protein intake and increase carbohydrate intake, improving survival through nutritional self-medication.