A. Khalil

Sex-based difference in immune responses and efficacy of the pneumococcal conjugate vaccine

This study examines sex-based differences in immune responses to the pneumococcal conjugate vaccine in mice, finding males have reduced antibody production and vaccine efficacy compared to females.

SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection

This study infects human pluripotent stem cell-derived vascular cells with SARS-CoV-2 and finds that smooth muscle cells drive vascular inflammation and coagulation.

Septin Organization is Regulated by the Gpa1 Ubiquitination Domain and Endocytic Machinery During the Yeast Pheromone Response.

This study shows that Gpa1 ubiquitination and endocytic machinery regulate septin organization during yeast pheromone response by controlling their localization at the polarity site.

Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors

The paper identifies SARS-CoV-2 variants resistant to protease inhibitors nirmatrelvir and ensitrelvir, showing pre-existing resistance and potential for spread.

A dolabralexin-deficient mutant provides insight into specialized diterpenoid metabolism in maize (Zea mays).

The paper identifies ZmKSL4 as the diterpene synthase for dolabralexin biosynthesis in maize and shows its role in root architecture under water deficit.

RIT1: A Novel Biomarker in Glioblastoma

This study identifies RIT1 as an oncogene in glioblastoma, showing its upregulation correlates with poor survival and STAT3 regulation, suggesting it as a potential biomarker and therapeutic target.

Genetically Encoded, Multivalent Liquid Glycan Array (LiGA)

The paper introduces LiGA, a platform for analyzing glycan-lectin interactions using DNA barcoded phage displaying glycans, enabling in vitro and in vivo binding studies.