Author

R. Derda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 6 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 1

Frequent Co-Authors

M. S. Macauley· 5 shared E. J. Carpenter· 4 shared M. Sojitra· 4 shared S. Sarkar· 4 shared A. Atrazhev· 3 shared E. A. Volker· 2 shared G. M. Lima· 2 shared T. L. Lowary· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersBiochemistry

M. S. Macauley

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Author profile →

7 papers

Recent·Most cited

Multivalent DNA-encoded lectins on phage enable detecting compositional glycocalyx differences

G. M. Lima, Z. J. Chenarboo, M. Sojitra, S. Sarkar, E. J. Carpenter, C. Y.-L. Yang, E. Schmidt, J. Lai, A. Atrazhev, D. Yazdan, C. Peng, E. A. Volker, R. Ho, G. Monteiro, R. Lai, , R. Derda

This paper develops a phage-based liquid lectin array to detect subtle glycocalyx differences by displaying multivalent lectins on DNA-barcoded M13 phage.

bioRxiv · Dec 13, 2023 · PreprintBiochemistry

Measuring carbohydrate recognition profile of lectins on live cells using liquid glycan array (LiGA)

M. Sojitra, E. N. Schmidt, G. M. Lima, E. J. Carpenter, K. A. McCord, A. Atrazhev, M. S. Macauley, R. Derda

This paper introduces a method to measure glycan recognition profiles of lectins on live cells using a liquid glycan array (LiGA) platform and next-generation sequencing.

bioRxiv · Oct 4, 2023Biochemistry

Phage display uncovers a sequence motif that drives polypeptide binding to a conserved regulatory exosite of O-GlcNAc transferase

M. G. Alteen, R. W. Meek, S. Kolappan, J. A. Busmann, J. Cao, Z. O'Gara, R. Derda, G. J. Davies, D. J. Vocadlo

The paper identifies a peptide sequence motif that binds to OGT's exosite, causing allosteric inhibition through steric occlusion of the active site.

bioRxiv · Mar 15, 2023 · PreprintBiochemistry

Genetically-Encoded Discovery of Perfluoroaryl-Macrocycles that Bind to Albumin and Exhibit Extended Circulation in-vivo

J. Y. K. Wong, S. E. Kirberger, R. Qiu, A. I. Ekanayake, P. Kelich, S. Sarkar, E. R. Alvizo-Paez, J. Miao, S. Kalhor-Monfared, J. J. Dwyer, J. M. Nuss, Y.-S. Lin, M. S. Macauley, L. Vukovic, W. C. K. Pomerantz, R. Derda

This paper identifies perfluoroaryl-macrocycle peptides that bind to albumin and have extended circulation in vivo through phage display and chemical modification.

bioRxiv · Aug 22, 2022Biochemistry

Chemoenzymatic Synthesis of Genetically-Encoded Multivalent Liquid N-glycan Arrays

C.-L. Lin, M. Sojitra, E. J. Carpenter, E. S. Hayhoe, S. Sarkar, E. A. Volker, A. Atrazhev, T. L. Lowary, M. S. Macauley, R. Derda

This paper develops a method to synthesize genetically-encoded multivalent liquid N-glycan arrays and evaluates their interaction with glycan-binding proteins in vitro and in vivo.

bioRxiv · Aug 5, 2022Biochemistry

Reproducible Discovery of Cell-Binding Peptides "Lost" in Bulk Amplification via Emulsion Amplification in Phage Display Panning

W. L. Matochko, F. Deiss, Y. Yang, R. Derda

This paper identifies cell-binding peptides missed in bulk phage display by using emulsion amplification to reduce growth bias in phage libraries.

bioRxiv · Oct 31, 2021 · PreprintBioengineering

Genetically Encoded, Multivalent Liquid Glycan Array (LiGA)

M. Sojitra, S. Sarkar, J. Maghera, E. Rodrigues, E. J. Carpenter, S. Seth, D. F. Vinals, N. J. Bennett, R. Reddy, A. Khalil, X. Xue, M. Bell, R. B. Zheng, P. Zhang, C. Nycholat, , R. Derda

The paper introduces LiGA, a platform for analyzing glycan-lectin interactions using DNA barcoded phage displaying glycans, enabling in vitro and in vivo binding studies.

bioRxiv · Mar 24, 2020Biochemistry