Author

A. Kovach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

H. Li· 4 shared G. Zhao· 2 shared A. J. Darwin· 1 shared B. K. Jain· 1 shared D. G. Thanassi· 1 shared G. Clucas· 1 shared G. T. Werneburg· 1 shared H. Chauhan· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBiochemistry

H. Li

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5 papers

Recent·Most cited

Pseudomonas aeruginosa C-terminal processing protease CtpA assembles into a hexameric structure that requires activation by a spiral-shaped lipoprotein binding partner

H.-C. Hsu, M. Wang, A. Kovach, A. J. Darwin, H. Li

This paper reports the structure and function of Pseudomonas aeruginosa CtpA, showing it forms an inactive hexamer that requires the spiral-shaped lipoprotein LbcA for activation and substrate delivery.

bioRxiv · Aug 9, 2021Biochemistry

Processive Dynamics of the Usher Assembly Platform During Uropathogenic Escherichia coli P Pilus Biogenesis

M. Du, Z. Yuan, G. T. Werneburg, N. S. Henderson, H. Chauhan, A. Kovach, G. Zhao, J. Johl, H. Li, D. G. Thanassi

The paper determines cryo-EM structures of the activated PapC usher during P pilus biogenesis, revealing processive steps and conformational dynamics.

bioRxiv · Dec 23, 2020Microbiology

Transport mechanism of class-3 P4 ATPase lipid flippases

L. Bai, Q. You, B. K. Jain, A. Kovach, T. R. Graham, H. Li

This study reveals the transport mechanism of class-3 P4 ATPases by analyzing their structure and function, showing conserved lipid-flipping mechanisms and unique features.

bioRxiv · Aug 25, 2020 · PreprintBiochemistry

Divergent selection and drift shape the genomes of two avian sister species spanning a saline-freshwater ecotone

J. Walsh, G. Clucas, M. MacManes, K. Thomas, A. Kovach

This study compares the genomes of two avian sister species to assess the roles of divergent selection and genetic drift in shaping their divergence across a saline-freshwater ecotone.

bioRxiv · Jun 12, 2018Evolutionary Biology

Proteasome Substrate Capture and Gate Activation by Mycobacterium tuberculosis PafE

K. Hu, J. B. Jastrab, S. Zhang, A. Kovach, G. Zhao, K. H. Darwin, H. Li

This study identifies PafE as an ATP-independent proteasome activator in M. tuberculosis, revealing its mechanism of substrate capture and gate activation through structural and functional analyses.

bioRxiv · Jan 16, 2018Biochemistry