L. Bai

Structural details of helix-mediated TDP-43 C-terminal domain multimerization

This study investigates the structural basis of TDP-43 C-terminal domain multimerization using biophysical experiments, AlphaFold2-Multimer, and simulations, revealing helical oligomerization and the role of specific residues in phase separation and disease.

Targeting CD19 for the treatment of autoimmune with a novel T cell engager

This study develops YK012, a T cell engager targeting CD19, showing potential for treating autoimmune diseases with improved efficacy and reduced side effects compared to existing therapies.

Serine hydroxymethyl transferase is a binding target of caprylic acid: Uncovering a novel molecular target for a herbicide and for producing caprylic acid-tolerant crops

This study identifies serine hydroxymethyl transferase (SHMT) as a binding target of caprylic acid, showing its role in herbicidal activity and potential for developing tolerant crops.

PPARγ controls ESCRT-dependent fibroblast-like synoviocyte exosome biogenesis and Alleviates Chondrocyte Osteoarthritis Mediated by Exosomal ANXA1

This study shows that PPARγ enhances exosome biogenesis in fibroblast-like synoviocytes via the ESCRT pathway, and these exosomes containing ANXA1 alleviate osteoarthritis by inhibiting ERK phosphorylation and chondrocyte apoptosis.

Synergistic effects of multiple pesticides on the flight ability of honey bees (Apis cerana F.)

This study shows that combinations of imidacloprid, chlorpyrifos, and glyphosate synergistically reduce flight ability in honey bees, while individual pesticides do not.

Structure of a fungal 1,3-β-glucan synthase

This study determines the cryo-EM structure of Saccharomyces cerevisiae 1,3-β-glucan synthase Fks1, revealing its catalytic mechanism and the role of disulfide bonds in enzymatic activity.

Study on the mechanism of HE4 in hyperoxia-induced alveolar damage in rats

This study examines how HE4 contributes to hyperoxia-induced alveolar damage in rats by activating ERK and p65, modulating MMP9 and TIMP1 pathways, and promoting fibrosis.

A Unified Catalog of 19,251 Non-human Reference Species Genomes Provides New Insights into the Mammalian Gut Microbiomes

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome depleted regions

This study shows how Cbf1's HLH region interacts with histones to slow nucleosome dissociation, enabling chromatin opening.

Enteroendocrine cell types that drive food reward and aversion

The paper identifies enteroendocrine cell subtypes that influence food reward and aversion through distinct signaling pathways in mice.

Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons

The paper shows that Lactiplantibacillus plantarum uses r/tRNA operons to communicate with Drosophila, activating GCN2 in enterocytes to promote systemic growth.

Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

Nucleosome-directed replication origin licensing independent of a consensus DNA sequence

This study shows that the yeast origin recognition complex can bind nucleosomes and license replication origins without requiring a consensus DNA sequence, suggesting this mechanism is conserved across eukaryotes.

Structural basis of the P4B ATPase lipid flippase activity

This study reports the first structure of a P4B ATPase, Neo1, and shows it uses a conserved mechanism for substrate transport similar to dimeric flippases.

A cold shock protein from a thermophile bacterium promotes the high-temperature growth of bacteria and fungi through binding to diverse RNA species

Co-infection of influenza A virus enhances SARS-CoV-2 infectivity

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

Transport mechanism of class-3 P4 ATPase lipid flippases

This study reveals the transport mechanism of class-3 P4 ATPases by analyzing their structure and function, showing conserved lipid-flipping mechanisms and unique features.

Association of gut microbiota with cerebral cortex and cerebrovascular abnormality in human mild traumatic brain injury

This study identifies gut microbiota changes and their associations with cerebral cortex and cerebrovascular abnormalities in human mild traumatic brain injury.

Transcriptomic analyses revealed the effect of Funneliformis mosseae on differentially expressed genes in Fusarium oxysporum

This study investigates how F. mosseae affects gene expression in F. oxysporum-infected soybean roots, identifying differentially expressed genes and their biological functions.

Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

Ctf4 organizes sister replisomes and Pol alpha into a replication factory

The paper shows Ctf4 organizes sister replisomes and Pol alpha into a replication factory by dimerizing CMG helicase and binding one Pol-primase.

DNA unwinding mechanism of a eukaryotic replicative CMG helicase

The paper reports the cryo-EM structure of the eukaryotic CMG helicase on forked DNA, revealing a 'dam-and-diversion tunnel' mechanism for DNA unwinding.

CAT1/SLC7A1 acts as a cellular receptor for bovine leukemia virus infection

This paper identifies CAT1/SLC7A1 as the cellular receptor for bovine leukemia virus (BLV) infection, showing it mediates viral entry and is essential for BLV susceptibility across species.

Fine Tuning of Histone Demethylase KDM6A/B Improves the Development of Nuclear Transfer Embryo

This study shows that overexpressing KDM6A improves SCNT efficiency, while knocking down KDM6B facilitates ZGA and reduces ectopic Xist expression in reprogramming.

Extracellular HBV RNAs are heterogeneous in length and circulate as virions and capsid-antibody-complexes in chronic hepatitis B patients

This study identifies extracellular HBV RNAs as heterogeneous in length, present in virions and capsid-antibody-complexes in CHB patients, and capable of serving as templates for viral DNA synthesis.