A. Layton

Modeling Sex Differences in the Effects of Diuretics in Renal Epithelial Transport during Angiotensin II-induced Hypertension

This study develops sex-specific computational models to analyze how diuretics affect renal electrolyte transport differently in male and female rats under hypertension.

Modeling magnesium and calcium transport along male rat kidney and the effects of diuretics

The paper develops computational models of renal Ca2+ and Mg2+ transport in male rats to study the effects of diuretics on electrolyte handling.

Impact of angiotensin-receptor blockers on intrarenal renin-angiotensin system activity in hypertension: A PK/PD modelling study

This study uses PK/PD modeling to show ARBs like Losartan more effectively inhibit intrarenal RAS by blocking Ang II uptake, reducing downstream signaling and normalizing blood pressure in rats.

Coupling of renal sodium and calcium transport: A modeling analysis

This study develops a computational model of renal electrolyte transport in rats to analyze sex differences in calcium and sodium handling and responses to pharmacological interventions.

Sex and time-of-day differences in kidney oxygen consumption

This study uses computational models to show sex and time-of-day differences in kidney oxygen consumption and the effect of loop diuretics on renal oxygenation in rats.

Determinants of natriuretic, diuretic, and kaliuretic effects of diuretics: Sex and administration time

This study uses computational models to show sex and time-of-day differences in diuretic effects, with loop diuretics showing larger effects during the active phase and K+-sparing diuretics showing sex-specific time differences.

A Complete Set of Equations for a Computational Model of Electrolyte and Water Transport along the Nephrons in a Mammalian Kidney

The paper develops and presents a computational model of electrolyte and water transport along nephrons in a mammalian kidney under various conditions.

Modelling Sex Differences in Circadian Regulation of Kidney Function of the Mouse

This study develops computational models to simulate sex differences in circadian regulation of kidney function in mice, revealing sex-specific effects on Na+ and K+ transport.

A Comparative Study of Epithelial Transport in the Rat and Mouse Kidneys: Modelling and Analysis

The paper develops sex-specific computational models of renal transport in rat and mouse kidneys to analyze sex and species differences in Na+ reabsorption and urine excretion.

A Complete Set of Equations and Parameters for the Computational Model of Mitochondrial Function for the Proximal Convoluted Tubule and Medullary Thick Ascending Limb Cells in the Rat Kidney

The paper develops and applies computational models of mitochondrial function in rat kidney cells under varying oxygenation levels, predicting key cellular quantities and providing a complete set of equations and parameters.

A Model of Mitochondria in the Rat Hepatocyte

The paper introduces a model of mitochondrial ATP generation in rat hepatocytes, predicting reduced electron transport chain states and reactive oxygen species production during ischemia-reperfusion.

A Mathematical Model of Mitochondria in Proximal Tubule and Thick Ascending Limb Cells

This paper develops a mathematical model of mitochondrial ATP generation in kidney and liver tissues to predict their responses to various mitochondrial dysfunctions and explain differences in their robustness.

Sex-specific Effects of SGLT2 Inhibition in a Kidney with Reduced Nephron Number: Modeling and Analysis

This study models and analyzes sex-specific effects of SGLT2 inhibition on kidney function in diabetic patients with and without uninephrectomy.

The intrarenal renin-angiotensin system in hypertension: Insights from mathematical modelling

This study uses computational modeling to show that AT1R-mediated uptake, not increased local Ang II production, drives intrarenal Ang II accumulation during Ang II infusion, contributing to hypertension.

Determining Risk Factors for Triple Whammy Acute Kidney Injury

The paper uses computational models to identify physiological factors that increase susceptibility to triple whammy acute kidney injury.

Sex-Specific Computational Models of Kidney Function in Human Patients with Diabetes

This study develops sex-specific computational models of kidney function in diabetic patients to analyze sex differences in renal transport and response to SGLT2 inhibition.

Sex Differences in Solute and Water Handling in the Human Kidney: Modeling and Functional Implications

The paper develops sex-specific models of solute and water transport in the human kidney, identifying transport parameter differences between males and females that explain sex-related differences in urine output, blood pressure regulation, and response to ACE inhibitors.

Characterization of a new Leishmania major isolate for use in a controlled human infection model

This paper isolates and characterizes a new Leishmania major strain for use in controlled human infection models to advance vaccine development.