P. Dutta

Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas

This study shows that mutant GNAS drives a gastric metaplasia gene signature and glycolytic dependency in IPMNs, offering a therapeutic target.

Haplo-insufficiency of Profilin1 in vascular endothelial cells is beneficial but not sufficient to confer protection against experimentally induced atherosclerosis

This study shows that partial loss of Profilin1 in vascular endothelial cells has some protective effects against atherosclerosis but is not enough to fully prevent it.

The actin-associated protein Kaptin modulates F-actin barbed-end dynamics

This study identifies Kaptin as a novel actin regulator that inhibits nucleation and caps barbed ends, stabilizing and bundling actin filaments.

Modeling magnesium and calcium transport along male rat kidney and the effects of diuretics

The paper develops computational models of renal Ca2+ and Mg2+ transport in male rats to study the effects of diuretics on electrolyte handling.

Coupling of renal sodium and calcium transport: A modeling analysis

This study develops a computational model of renal electrolyte transport in rats to analyze sex differences in calcium and sodium handling and responses to pharmacological interventions.

Sex and time-of-day differences in kidney oxygen consumption

This study uses computational models to show sex and time-of-day differences in kidney oxygen consumption and the effect of loop diuretics on renal oxygenation in rats.

Determinants of natriuretic, diuretic, and kaliuretic effects of diuretics: Sex and administration time

This study uses computational models to show sex and time-of-day differences in diuretic effects, with loop diuretics showing larger effects during the active phase and K+-sparing diuretics showing sex-specific time differences.

Atypical B cells consist of subsets with distinct effector functions

The paper identifies three distinct subsets of atypical B cells with unique transcriptional and functional profiles in individuals with chronic Plasmodium falciparum exposure.

Development of methylation-based biomarkers for breast cancer detection by model training and validation in synthetic cell-free DNA

This study develops methylation-based biomarkers for breast cancer detection using synthetic cell-free DNA and validates their performance with in vitro testing.

Heterotrimeric kinesin-2 motor subunit, KLP68D, localises Drosophila odour receptor coreceptor in the distal domain of the olfactory cilia

This paper shows that the Drosophila odor receptor coreceptor (Orco) enters olfactory cilia in two stages post-eclosion and is localized to the distal ciliary domain by the kinesin-2 motor complex.

Expression of Toll like Receptor 4 in the ductal epithelial cells of the Breast tumor microenvironment is correlated with the invasiveness of the tumor

The paper investigates TLR4 expression in breast tumors and finds it correlates with invasiveness and lymph node involvement, with differential effects in TP53 wild-type and mutant cells.

Coupling of dynamic microtubules to F-actin by Fmn2 regulates chemotaxis of neuronal growth cones

This study identifies Fmn2 as a regulator of actin-microtubule crosstalk in neuronal growth cones, showing its role in chemotaxis and microtubule stabilization.

Planar cell polarity in the C. elegans embryo emerges by differential retention of aPARs at cell-cell contacts

This study shows how planar cell polarity in C. elegans embryos forms through asymmetric retention of aPARs at cell-cell contacts, involving Wnt signaling and Rho GTPases.

Non Diaphanous Formin Delphilin Acts as a Barbed End Capping Protein

This study shows Delphilin, a formin with PDZ and FH domains, acts as a barbed end capping protein by inhibiting actin filament elongation and depolymerization.