Author

H. Ashwin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

N. Brown· 3 shared P. M. Kaye· 3 shared A. Romano· 2 shared G. F. Rani· 2 shared J. S. P. Doehl· 2 shared K. Van Bocxlaer· 2 shared M. Osman· 2 shared N. S. Dey· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

N. Brown

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19

J. T. H. Lee, S. N. Barnett, K. Roberts, H. Ashwin, L. Milross, J.-W. Cho, A. Huseynov, B. Woodhams, A. Aivazidis, T. Li, J. Majo, P. C. Guerrero, M. Lee, A. M. A. Miranda, Z. Jablonska, , O. A. Bayraktar

This study integrates single-cell and spatial transcriptomics with histopathology to identify cellular and molecular changes in lung alveolar damage during COVID-19 progression.

bioRxiv · Dec 20, 2023Pathology

UVB modifies skin immune-stroma cross-talk and promotes effector T cell recruitment during cryptic Leishmania donovani infection

M. Montes de Oca, S. Dey, K. Van Bocxlaer, H. Ashwin, N. Brown, E. Myburgh, N. S. Dey, G. F. Rani, E. Muscutt, M. Osman, D. Perez-Mazliah, S. James, L. Gilbert, M. Chatterjee, P. Kaye

This study uses scRNA-seq and spatial transcriptomics to show UVB exposure alters immune-stromal interactions and T cell recruitment during cryptic Leishmania donovani infection.

bioRxiv · Feb 3, 2023 · PreprintImmunology

Spatial point pattern analysis identifies mechanisms shaping the skin parasite landscape in Leishmania donovani infection

J. S. P. Doehl, H. Ashwin, N. Brown, A. Romano, S. Carmichael, J. W. Pitchford, P. M. Kaye

The paper uses spatial point pattern analysis to study parasite dispersal in L. donovani infection, revealing patchy distribution and spread through recruited myeloid cells.

bioRxiv · May 7, 2021Microbiology

Interferon-γ-producing CD4+ T cells drive monocyte activation in the bone marrow during experimental Leishmania donovani infection.

A. Romano, N. Brown, H. Ashwin, J. S. P. Doehl, J. Hamp, M. Osman, N. S. Dey, G. F. Rani, T. R. Ferreira, P. M. Kaye

This study shows CD4+ T cells produce IFN-γ to activate bone marrow monocytes during Leishmania donovani infection, enhancing parasite control.

bioRxiv · Apr 26, 2021Immunology

Characterization of a new Leishmania major isolate for use in a controlled human infection model

H. Ashwin, J. Sadlova, B. Vojtkova, T. Becvar, P. Lypaczewski, E. Schwartz, E. Greensted, K. Van Bocxlaer, M. Pasin, K. Lipinski, V. Parkash, G. Matlashewski, A. Layton, C. Lacey, C. Jaffe, , P. Kaye

This paper isolates and characterizes a new Leishmania major strain for use in controlled human infection models to advance vaccine development.

bioRxiv · Aug 12, 2020Microbiology