SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis
A. Ferrena, J. Wang, R. Zhang, B. Karadal-Ferrena, W. al-Hardan, S. Singh, H. Borjihan, E. Schwartz, H. Zhao, R. Yang, D. Geller, B. Hoang, D. Zheng
This study shows SKP2 knockout in osteosarcoma mouse models increases immune infiltration and correlates with improved patient survival.
bioRxiv · May 9, 2023Cancer Biology