Author

T. E. Sutherland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 8

Signature Assays, Organisms & Methods

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Organism:mouse· 8 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

J. E. Allen· 6 shared B. H. Chan· 3 shared J. Ajendra· 3 shared J. E. Parkinson· 3 shared J. Parkinson· 3 shared S. Pearson· 3 shared A. L. Chenery· 2 shared A. S. MacDonald· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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6 shared papersImmunology

J. E. Allen

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8 papers

Recent·Most cited

Allergen-induced airway matrix remodelling in mice can be prevented or reversed by targeting chitinase-like proteins.

J. E. Parkinson, A. D. Adamson, A. S. MacDonald, J. E. Allen, T. E. Sutherland

This study shows that targeting chitinase-like proteins can prevent or reverse allergen-induced airway matrix remodelling in mice, independent of ongoing inflammation.

bioRxiv · Aug 18, 2023 · PreprintImmunology

IL-17A promotes epithelial cell IL-33 production during nematode lung migration

J. Ajendra, S. Pearson, J. Parkinson, B. H. K. Chan, H. J. McSorley, T. E. Sutherland, J. E. Allen

This study shows IL-17A promotes IL-33 production in lung epithelial cells during nematode infection, independent of IFN-gamma suppression.

bioRxiv · Nov 3, 2022 · PreprintImmunology

The magnitude of airway remodelling is not altered by distinct allergic inflammatory responses in BALB/c vs C57BL/6 mice but matrix composition differs

J. E. Parkinson, S. Pearson, D. Ruckerl, J. E. Allen, T. E. Sutherland

bioRxiv · Oct 20, 2020Immunology

IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection

A. L. Chenery, S. Rosini, J. Parkinson, J. A. Herrera, C. Lawless, B. H. Chan, P. A. Loke, A. S. MacDonald, K. Kadler, T. E. Sutherland, J. E. Allen

This study shows that IL-13 reduces lung damage and supports epithelial type 2 molecule production during nematode infection in mice.

bioRxiv · Oct 14, 2020Immunology

IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type 2 immune response to nematode infection

J. Ajendra, A. L. Chenery, J. E. Parkinson, B. H. Chan, S. Pearson, S. A. Colombo, L. Boon, R. K. Grencis, T. E. Sutherland, J. E. Allen

This study shows IL-17A suppresses IFNγ to initiate and later limits type-2 immune responses in the lung during nematode infection.

bioRxiv · Apr 18, 2020Immunology

Ongoing exposure to peritoneal dialysis fluid alters resident peritoneal macrophage phenotype and activation propensity

T. E. Sutherland, T. N. Shaw, R. Lennon, S. E. Herrick, D. Rückerl

This study shows that long-term exposure to peritoneal dialysis fluid changes peritoneal macrophage function, increasing inflammation and reducing tissue resident cell survival in mice.

bioRxiv · Mar 2, 2020Immunology

Inflammasome-independent role for NLRP3 in controlling innate anti-helminth immunity and tissue repair in the lung

A. Chenery, R. Alhallaf, Z. Agha, J. Ajendra, J. Parkinson, M. M. Cooper, B. H. Chan, R. M. Eichenberger, L. A. Dent, A. A. Robertson, A. Kupz, D. Brough, A. Loukas, T. E. Sutherland, J. E. Allen, P. Giacomin

This study shows NLRP3 limits lung neutrophilia and helminth killing in an inflammasome-independent way, while promoting tissue repair.

bioRxiv · Jun 7, 2019Immunology

A helminth chitinase structurally similar to mammalian chitinase displays immunomodulatory properties

F. Ebner, K. Balster, K. Janek, A. Niewienda, P. H. Malecki, M. S. Weiss, T. E. Sutherland, A. Heuser, A. A. Kühl, J. Zentek, A. Hofmann, S. Hartmann

This paper identifies a helminth chitinase with immunomodulatory effects in a murine allergic model, showing structural similarity to mammalian chitinase and inducing cross-reactive antibodies.

bioRxiv · May 17, 2019 · PreprintImmunology