Author

A. N. Lau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:metabolism & bioenergetics· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. G. Vander Heiden· 4 shared L. V. Danai· 3 shared S. Sivanand· 3 shared A. M. Darnell· 2 shared A. M. Westermark· 2 shared E. C. Lien· 2 shared M. Vander Heiden· 2 shared O. H. Yilmaz· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCancer Biology

M. G. Vander Heiden

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Author profile →

6 papers

Recent·Most cited

Effects of aging on glucose and lipid metabolism in mice

E. C. Lien, N. Vu, A. M. Westermark, L. V. Danai, A. N. Lau, Y. Gultekin, M. A. Kukurugya, B. D. Bennett, M. Vander Heiden

This study examines how aging affects glucose and lipid metabolism in mice, finding that NAD+ levels remain stable but lipid metabolism increases in aged tissues.

bioRxiv · Dec 17, 2023Physiology

Cancer tissue of origin constrains the growth and metabolism of metastases

S. Sivanand, Y. Gultekin, P. Winter, S. Y. Vermeulen, K. Tchourine, K. L. Abbott, L. V. Danai, F. Gourgue, B. T. Do, K. Crowder, T. Kunchok, A. N. Lau, A. M. Darnell, A. Jefferson, S. Morita, , M. G. Vander Heiden

This study shows that cancer tissue-of-origin influences the metabolism and growth preferences of both primary and metastatic tumors.

bioRxiv · Aug 17, 2022Cancer Biology

Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors

R. Datta, A. N. Lau, S. Sivanand, L. Florek, J. Wyckoff, M. C. Skala, M. G. Vander Heiden

The paper investigates how interactions with pancreatic stromal cells affect the redox state of cancer cells, finding that these interactions promote a more oxidized redox state in cancer cells.

bioRxiv · Oct 20, 2020Cancer Biology

Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblastdriven nutritional support and immunosuppression

R. Francescone, D. Barbosa Vendramini-Costa, J. Franco-Barraza, J. Wagner, A. Muir, A. N. Lau, L. Gabitova, T. Pazina, S. Gupta, T. Luong, N. Shah, D. Rollins, R. Malik, R. Thapa, D. Restifo, , E. Cukierman

This study identifies Netrin G1 as a promoter of pancreatic ductal adenocarcinoma tumorigenesis by enhancing cancer-associated fibroblast-driven metabolic support and immunosuppression.

bioRxiv · May 30, 2020Cancer Biology

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

A. N. Lau, Z. Li, L. V. Danai, A. M. Westermark, A. M. Darnell, R. Ferreira, V. Gocheva, S. Sivanand, E. C. Lien, K. M. Sapp, J. R. Mayers, G. Biffi, C. R. Chin, S. M. Davidson, D. A. Tuveson, , M. Vander Heiden

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.

bioRxiv · Mar 9, 2020Cancer Biology

Pancreatic Stellate Cells Secrete Deoxycytidine Conferring Resistance to Gemcitabine in PDAC

S. Dalin, M. R. Sullivan, E. Kreidl, A. N. Lau, B. Grauman-Boss, S. Fenoglio, A. Luengo, M. G. Vander Heiden, D. A. Lauffenburger, M. T. Hemann

This study shows that pancreatic stellate cells secrete deoxycytidine, which reduces the effectiveness of gemcitabine in PDAC by inhibiting its processing in cancer cells.

Cancer Research · Nov 15, 2019Peer-reviewedCancer Biology