Author

B. T. Do

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 4 Research Focus:metabolism & bioenergetics· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

M. G. Vander Heiden· 5 shared C. A. Lewis· 4 shared A. Ali· 3 shared K. L. Abbott· 3 shared A. M. Darnell· 2 shared A. Muir· 2 shared D. R. Schmidt· 2 shared N. J. Matheson· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCancer Biology

M. G. Vander Heiden

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

K. L. Abbott, A. Ali, D. Casalena, B. T. Do, R. Ferreira, J. H. Cheah, C. K. Soule, A. Deik, T. Kunchok, D. R. Schmidt, S. Renner, S. E. Honeder, M. Wu, S. H. Chan, T. Tseyang, , M. G. Vander Heiden

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

bioRxiv · Feb 25, 2023Cancer Biology

Cancer tissue of origin constrains the growth and metabolism of metastases

S. Sivanand, Y. Gultekin, P. Winter, S. Y. Vermeulen, K. Tchourine, K. L. Abbott, L. V. Danai, F. Gourgue, B. T. Do, K. Crowder, T. Kunchok, A. N. Lau, A. M. Darnell, A. Jefferson, S. Morita, , M. G. Vander Heiden

This study shows that cancer tissue-of-origin influences the metabolism and growth preferences of both primary and metastatic tumors.

bioRxiv · Aug 17, 2022Cancer Biology

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

B. T. Do, P. P. Hsu, S. Y. Vermeulen, Z. Wang, T. Hirz, K. L. Abbott, N. Aziz, J. M. Replogle, S. Bjelosevic, J. Paolino, S. Nelson, S. Block, A. M. Darnell, R. Ferreira, H. Zhang, , M. G. Vander Heiden

The paper shows that nucleotide depletion and DNA replication stress drive cell fate transitions in hematopoietic systems by activating lineage-specific maturation genes.

bioRxiv · Aug 16, 2022Cancer Biology

Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

B. I. Reinfeld, M. Z. Madden, M. M. Wolf, A. Chytil, J. E. Bader, A. R. Patterson, A. S. Cohen, A. Ali, B. T. Do, C. A. Lewis, A. Muir, R. A. Hongo, K. L. Young, R. E. Brown, V. M. Todd, , W. K. Rathmell

The paper measures nutrient uptake in the tumor microenvironment using PET tracers and finds cancer cells prefer glutamine while myeloid cells consume most glucose.

bioRxiv · Aug 10, 2020 · PreprintCancer Biology

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

A. Luengo, Z. Li, D. Y. Gui, L. B. Sullivan, M. Zagorulya, B. T. Do, R. Ferriera, A. Naamati, A. Ali, C. A. Lewis, C. J. Thomas, S. Spranger, N. J. Matheson, M. G. Vander Heiden

The paper shows that increased NAD+ demand relative to ATP demand drives aerobic glycolysis by impairing NAD+ regeneration and promoting fermentation.

bioRxiv · Jun 8, 2020Biochemistry