Author

A. Mukundan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. P. Hinck· 3 shared C. S. Hinck· 3 shared C. Schoenherr· 2 shared G. Inman· 2 shared M. P. J. White· 2 shared P. ten Dijke· 2 shared R. M. Maizels· 2 shared A. Sanders· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBiochemistry

A. P. Hinck

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3 papers

Recent·Most cited

TGM6, a helminth secretory product, mimics TGF-β binding to TβRII to antagonize TGF-β signaling in fibroblasts

S. E. White, T. A. Schwartze, A. Mukundan, C. Schoenherr, S. P. Singh, M. van Dinther, K. T. Cunningham, M. P. J. White, T. Campion, J. Pritchard, C. S. Hinck, P. ten Dijke, G. Inman, R. M. Maizels, A. P. Hinck

This paper shows TGM6, a helminth protein, mimics TGF-β binding to TβRII to inhibit TGF-β signaling in fibroblasts but not T cells.

bioRxiv · Dec 22, 2023 · PreprintBiochemistry

The helminth TGF-beta mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-beta receptors to preferentially target myeloid cells

S. Singh, D. J. Smyth, K. Cunningham, A. Mukundan, C.-H. Byron, C. S. Hinck, M. P. J. White, C. Ciancia, N. Wosowska, A. Sanders, R. Jin, S. Lilla, S. Zanivan, C. Schoenherr, G. Inman, , R. M. Maizels

This paper identifies TGM4, a helminth TGF-beta mimic, as a modular ligand that selectively targets myeloid cells through specific receptor interactions, differing from TGM1's broader T cell targeting.

bioRxiv · Nov 13, 2023 · PreprintImmunology

Structure-based mapping of the TβRI and TβRII receptor binding sites of the parasitic TGF-β mimic, Hp-TGM

A. Mukundan, C.-H. Byeon, C. S. Hinck, D. Smyth, R. Maizels, A. P. Hinck

This paper identifies the receptor binding sites of the parasitic TGF-β mimic Hp-TGM using biophysical methods, showing it binds to TβRI and TβRII through specific domains.

bioRxiv · Dec 8, 2020 · PreprintBiophysics