Author

D. Smyth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

R. Maizels· 3 shared A. Muir· 1 shared A. Mukundan· 1 shared A. P. Hinck· 1 shared A. Rossi· 1 shared B. Zhang· 1 shared C. Husovsky· 1 shared C. Minutti· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersImmunology

R. Maizels

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Exogenous TGFβ1 and its mimic HpTGM attenuate the heart's inflammatory response to ischaemic injury and improve long term cardiac outcomes

R. E. Redgrave, E. Singh, S. Tual-Chalot, C. Park, D. Hall, K. Bannaceur, D. Smyth, R. M. Maizels, I. Spyridopoulos, H. M. Arthur

This study shows that exogenous TGFβ1 and its mimic HpTGM reduce inflammation and infarct size after myocardial infarction, improving cardiac outcomes.

bioRxiv · Apr 18, 2023 · PreprintPathology

Metabolic regulation by prostaglandin E2 impairs lung group 2 innate lymphoid cell responses

C. Robb, Y. Zhou, J. Felton, B. Zhang, M. Goepp, P. Jheeta, D. Smyth, R. Breyer, S. Narumiya, H. McSorley, R. Maizels, J. Schwarze, A. Rossi, C. Yao

This study identifies that PGE2-EP2 signaling suppresses lung ILC2 responses and eosinophilic inflammation, while EP4 agonism restricts these responses, offering potential therapeutic targets for asthma and NERD.

bioRxiv · Dec 23, 2021Immunology

Structure-based mapping of the TβRI and TβRII receptor binding sites of the parasitic TGF-β mimic, Hp-TGM

A. Mukundan, C.-H. Byeon, C. S. Hinck, D. Smyth, R. Maizels, A. P. Hinck

This paper identifies the receptor binding sites of the parasitic TGF-β mimic Hp-TGM using biophysical methods, showing it binds to TβRI and TβRII through specific domains.

bioRxiv · Dec 8, 2020 · PreprintBiophysics

A macrophage-pericyte axis directs tissue restoration via Amphiregulin-induced TGFβ activation

R. Modak, C. Minutti, F. Macdonald, F. Li, D. Smyth, D. Dorward, N. Blair, C. Husovsky, A. Muir, R. Dobie, R. Maizels, T. Kendall, D. Griggs, M. Kopf, N. Henderson, D. Zaiss

This study identifies a macrophage-pericyte axis that promotes tissue restoration through Amphiregulin-induced TGFβ activation during acute injury.

bioRxiv · Jul 12, 2018 · PreprintImmunology