Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2
W. Wang, Y. Zhou, J. Wang, S. Zhang, A. Ozes, H. Gao, F. Fang, Y. Wang, X. Chu, Y. Liu, J. Wan, A. K. Mitra, H. M. O'Hagan, K. P. Nephew
This study shows that inhibiting HOTAIR and EZH2 reduces ovarian cancer stem cell resistance to platinum chemotherapy and improves survival in vivo.
bioRxiv · Jun 26, 2023Cancer Biology