Acetyl transferase EP300 deficiency leads to chronic replication stress mediated by defective fork protection at stalled replication forks
A. Barreto-Galvez, M. Niljikar, J. Gagliardi, R. Zhang, A. Juwarwala, A. Pradeep, V. Kumar, P. Tiwari, A. Shaikh, K. Sharma, J. Gerhardt, J. Cao, K. Kataoka, A. Durbin, J. Qi, , A. Madireddy
This paper shows that EP300 deficiency causes chronic replication stress and genomic instability in ATLL cells by impairing fork protection and leading to DNA damage and mitotic defects.
bioRxiv · Apr 29, 2023 · PreprintCancer Biology