Droplet and fibril formation of the functional amyloid Orb2
K. Ashami, A. S. Falk, C. Hurd, S. Garg, S. A. Cervantes Cortes, A. Rawat, A. B. Siemer
This study shows that Orb2 can form protein droplets via LLPS, but these droplets rapidly mature into fibrils, suggesting phase separation initiates fibril formation.
bioRxiv · Feb 19, 2021Biophysics