Aldosterone mediates potassium-induced kidney fibrosis through tubular and mesenchymal mineralocorticoid receptor activation
T. CHARLEMAGNE, A. SASSI, M. Gjorgjieva, r. yvon, M. Tournier, M. Fernandez, A. Chassot, I. Roth, C. Veyrat-Durebex, S. Ramakrishnan, J. Rutkowski, E. Feraille, V. Olivier
This study shows high dietary potassium worsens kidney fibrosis in mice by activating MR in tubular and mesenchymal cells, mediated by aldosterone.
bioRxiv · Jun 15, 2022 · PreprintPhysiology