M. J. Reynolds

This study shows bending forces induce structural changes in F-actin that depend on its nucleotide state, with phosphate stabilizing subunit conformations and altering the structural landscape.

Cryo-EM, biochemical, and cellular studies reveal how the crosslinking protein T-plastin bridges actin filaments in two opposing orientations.

This paper shows that medium-to-large extracellular vesicles (m/lEVs) protect brain endothelial cells by transferring mitochondria and reducing brain infarct sizes in a mouse stroke model.

This paper presents cryo-EM structures of myosin-15 bound to F-actin, revealing how mutations affect actin polymerization and stereocilia elongation.

This study shows that force on F-actin enhances E-catenin binding but not vinculin, revealing a modular mechanism for force-sensing by α-catenin.

This study investigates how PRC2 interacts with chromatin using single-molecule force spectroscopy and simulations, revealing new binding configurations and their regulation.