Author

A. Sockell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:clustering· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:organoid / primary culture· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

C. Curtis· 2 shared K. Karlsson· 2 shared Y.-H. Lo· 2 shared A. Khan· 1 shared A. Mah· 1 shared B. Lu· 1 shared C. J. Kuo· 1 shared C. J. Suarez· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBioengineering

C. Curtis

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2 papers

Recent·Most cited

A microwell platform for high-throughput longitudinal phenotyping and selective retrieval of organoids

A. Sockell, W. Wong, S. Longwell, T. Vu, K. Karlsson, D. A. Mokhtari, J. Schaepe, Y.-H. Lo, V. Cornelius, C. Kuo, D. A. Van Valen, C. Curtis, P. M. Fordyce

This paper introduces a microwell platform for high-throughput longitudinal phenotyping of organoids and their selective retrieval for molecular profiling, identifying genomic and expression changes linked to growth and polarity.

bioRxiv · Nov 1, 2022Bioengineering

Deterministic evolution and stringent selection during pre-neoplasia

K. Karlsson, M. J. Przybilla, E. Kotler, A. Khan, H. Xu, K. Karagyozova, A. Sockell, W. H. Wong, K. Liu, A. Mah, Y.-H. Lo, B. Lu, K. E. Houlahan, Z. Ma, C. J. Suarez, , C. Curtis

This study models pre-neoplasia in human gastric organoids by inactivating TP53, revealing progression to malignant transcriptional programs and clonal dynamics through experimental evolution.

bioRxiv · Apr 9, 2022 · PreprintCancer Biology