Cancer BiologybioRxivPreprint
Deterministic evolution and stringent selection during pre-neoplasia
K. Karlsson, M. J. Przybilla, E. Kotler…·C. Curtis
This study models pre-neoplasia in human gastric organoids by inactivating TP53, revealing progression to malignant transcriptional programs and clonal dynamics through experimental evolution.
DOI 10.1101/2022.04.09.487529