T. Vu

High dimensional analyses reveal activation of lymphocyte subsets and reversal of immunoresistance by cytokine enhancement of adoptive cellular vaccine therapy in prostate cancer.

This study shows IL-15 treatment enhances the anti-tumor efficacy of sipuleucel-T by increasing CD8+ T-cell and CD56+ NKT subset activity in prostate cancer.

A microwell platform for high-throughput longitudinal phenotyping and selective retrieval of organoids

This paper introduces a microwell platform for high-throughput longitudinal phenotyping of organoids and their selective retrieval for molecular profiling, identifying genomic and expression changes linked to growth and polarity.

Lipid phase separation in vesicles enhances TRAIL-mediated cytotoxicity

This study shows lipid phase separation on vesicles enhances TRAIL cytotoxicity by controlling protein density, with effects dependent on TRAIL receptor type.

Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis

This paper introduces MOSAICA, a spatial transcriptomics technology that combines spectral and lifetime encoding with machine learning to enable highly multiplexed in situ biomarker profiling.

Phylomedicine of mutational processes in somatic cancer cell populations

This study integrates cancer cell phylogeny with mutational signature deconvolution to track mutational process changes in lung cancer patients over time.

The Past, Present and Future of Elephant Landscapes in Asia

The paper quantifies historical and future habitat loss for Asian elephants across multiple scenarios, showing significant declines and the need for equitable policies.

Power and pitfalls of computational methods for inferring clone phylogenies and mutation orders from bulk sequencing data

This study evaluates seven computational methods for inferring clone phylogenies from bulk sequencing data, finding significant variation in their accuracy for mutation order and clone grouping.

A human ex vivo dengue virus neutralization assay identifies priority antibodies and epitopes for vaccines and therapeutics.

This study develops an ex vivo dengue virus neutralization assay using mosquitoes to identify potent human monoclonal antibodies and their epitopes for vaccine and therapeutic development.

Predicting clone genotypes from tumor bulk sequencing of multiple samples

The paper evaluates nine computational methods for inferring clone genotypes from bulk tumor sequencing data, finding that most perform poorly on datasets with mixed clonal lineages.

Computational enhancement of single-cell sequences for inferring tumor evolution

This paper introduces BEAM, a Bayesian method for improving single-cell tumor sequencing data by leveraging evolutionary information, showing it outperforms existing methods in imputing missing bases and correcting false positives/negatives.