Deterministic evolution and stringent selection during pre-neoplasia
K. Karlsson, M. J. Przybilla, E. Kotler, A. Khan, H. Xu, K. Karagyozova, A. Sockell, W. H. Wong, K. Liu, A. Mah, Y.-H. Lo, B. Lu, K. E. Houlahan, Z. Ma, C. J. Suarez, , C. Curtis
This study models pre-neoplasia in human gastric organoids by inactivating TP53, revealing progression to malignant transcriptional programs and clonal dynamics through experimental evolution.
bioRxiv · Apr 9, 2022 · PreprintCancer Biology