A. Suarez-Bonnet

Branched actin networks mediate macrophage-dependent host microbiota homeostasis.

This study shows that Arpc5-containing Arp2/3 complexes are critical for macrophage function and maintaining host-microbiota homeostasis, as their loss leads to intestinal inflammation.

Glutaminase as a metabolic target of choice to counter acquired resistance to Palbociclib by colorectal cancer cells

This study shows that combining Palbociclib with Telaglenestat prevents acquired resistance in colorectal cancer cells by counteracting metabolic reprogramming.

Blimp-1 and c-Maf regulate common and unique gene networks to protect against distinct pathways of pathobiont-induced colitis

This study shows Blimp-1 and c-Maf regulate gene networks in T cells to prevent colitis, with distinct roles in controlling inflammatory pathways in mouse models.

Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis

This study identifies ZDHHC20 as a palmitoyl transferase promoting pancreatic cancer metastasis by affecting tumor-immune interactions, with no effect on proliferation or primary tumor growth.

USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development

This study shows that USP7 inactivation suppresses intestinal tumor development in APC-mutant mice but causes colitis with prolonged deletion and is effective against patient-derived cancer organoids.

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

This study shows that targeted cancer therapy induces APOBEC-mediated mutagenesis, promoting drug resistance by increasing genetic diversity through mechanisms involving NF-κB activation and reduced DNA repair.