V. Pham

A novel iPSC model reveals selective vulnerability of neurons in Multiple Sulfatase Deficiency

This paper creates an iPSC model of Multiple Sulfatase Deficiency, showing that neurons become more vulnerable to SUMF1 loss during differentiation.

mt-LAF3 is a pseudouridine synthase ortholog required for mitochondrial rRNA and mRNA gene expression in Trypanosoma brucei

This study shows that mt-LAF3 is essential for mitochondrial rRNA and mRNA expression in T. brucei but lacks PUS catalytic activity, instead functioning as an RNA-stabilizing scaffold.

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

The paper presents cryo-EM structures of the M4 mAChR with ligands and modulators, revealing structural and dynamic insights into allosteric modulation and receptor activation mechanisms.

Contrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type1 diabetes therapeutic reversal in preclinical models

This paper shows contrast-enhanced ultrasound blood-flow measurements predict therapeutic success in preclinical T1D models.

Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis and beta-cell mass decline in mouse models of type 1 diabetes

Molecular bases for the constitutive photomorphogenic phenotypes in Arabidopsis

The paper identifies molecular mechanisms underlying constitutive photomorphogenic phenotypes in Arabidopsis by showing PIF instability in cop1 mutants and PIF overexpression suppresses these phenotypes.