Author

K. Leach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Assay:cryo-EM· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. Christopoulos· 2 shared A. Glukhova· 2 shared C. E. Vorwald· 2 shared M. J. Belousoff· 2 shared R. Danev· 2 shared Y.-L. Liang· 2 shared A. Bhattarai· 1 shared A. C. Filler· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Christopoulos

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6 papers

Recent·Most cited

Conductive microgel annealed scaffolds enhance myogenic potential of myoblastic cells

A. Casella, J. Lowen, N. Shimamoto, K. H. Griffin, A. C. Filler, A. Panitch, K. Leach

The paper shows conductive microgel scaffolds enhance myogenic differentiation of myoblastic cells by improving late-stage markers and promoting factors associated with muscle repair.

bioRxiv · Aug 1, 2023Bioengineering

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

Z. Vuckovic, J. Wang, V. Pham, J. I. Mobbs, M. J. Belousoff, A. Bhattarai, W. A. C. Burger, G. Thompson, M. Yeasmin, K. Leach, E. T. van der Westhuizen, E. Khajehali, Y.-L. Liang, A. Glukhova, D. Wootten, , D. M. Thal

The paper presents cryo-EM structures of the M4 mAChR with ligands and modulators, revealing structural and dynamic insights into allosteric modulation and receptor activation mechanisms.

bioRxiv · Sep 27, 2022Pharmacology & Toxicology

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

G. Deganutti, Y.-L. Liang, X. Zhang, M. Khoshouei, L. Clydesdale, M. J. Belousoff, H. Venugopal, T. T. Truong, A. Glukhova, A. N. Keller, K. J. Gregory, K. Leach, A. Christopoulos, R. Danev, C. A. Reynolds, , D. M. Wootten

The paper investigates how different GLP-1R agonists affect G protein activation kinetics through structural and functional analyses.

bioRxiv · Mar 10, 2021Biochemistry

Evaluation of Alginate-Based Bioinks for 3D Bioprinting, Mesenchymal Stromal Cell Osteogenesis, and Application for Patient-Specific Bone Grafts

T. Gonzalez Fernandez, A. Tenorio, K. T. Campbell, E. A. Silva, K. Leach

This study evaluates four alginate-based bioinks for 3D bioprinting, finding that alg-CaCl2 supports better cell viability and osteogenic differentiation compared to other bioinks.

bioRxiv · Aug 9, 2020Bioengineering

Hydrogel mechanical properties are more important than osteoinductive growth factors for bone formation with MSC spheroids

J. Whitehead, K. E. Griffin, C. E. Vorwald, M. Gionet-Gonzales, S. Cinque, K. Leach

This study shows that viscoelastic hydrogel properties enhance bone formation by MSC spheroids more than BMP-2 growth factors.

bioRxiv · Mar 10, 2020 · PreprintBioengineering

Tunable Fibrin-Alginate Interpenetrating Network Hydrogels to Guide Cell Behavior

C. E. Vorwald, T. Gonzalez-Fernandez, S. Joshee, P. Sikorski, K. Leach

This paper develops a fibrin-alginate hydrogel to decouple cell adhesion from hydrogel stiffness, showing increased cell area and circularity in softer gels.

bioRxiv · Oct 24, 2019 · PreprintBioengineering