A. W. Reinke

The paper screens the Pandemic Response Box to identify anti-microsporidia compounds using C. elegans infected with Nematocida parisii, finding four effective inhibitors.

This study sequenced nine nematode-infecting microsporidia genomes, revealing conserved metabolic pathways, horizontally transferred genes, and variable phenotypic traits across species.

This study screens FDA-approved compounds and natural products to identify inhibitors of microsporidia infection in C. elegans, finding five compounds that block spore firing and one that slows infection progression.

This study identifies a secreted host protein, AAIM-1, that promotes microsporidia invasion of C. elegans and reveals trade-offs in host defense against different pathogens.

The paper creates a database of 1,440 microsporidia species and analyzes their ecological and phenotypic diversity, finding broad host ranges and polar tube length as a determinant of tissue specificity.

The paper shows that parental transcriptional responses to microsporidia infection induce inherited immunity in offspring, protecting them against both microsporidia and bacterial pathogens.