Phosphorylation barcodes direct biased chemokine signaling at CXCR3
D. S. Eiger, J. S. Smith, T. Shi, T. M. Stepniewski, C.-F. Tsai, C. Honeycutt, N. Boldiszar, J. Gardner, C. D. Nicora, A. M. Moghieb, K. Kawakami, I. Choi, K. Zheng, A. Warman, P. Alagesan, , S. Rajagopal
The paper shows that CXCR3 chemokines use different phosphorylation barcodes to activate distinct signaling pathways, leading to varied physiological outcomes.
bioRxiv · Mar 14, 2023Biochemistry