J. Teijaro

Transient EZH2 suppression by Tazemetostat during in vitro expansion maintains T cell stemness and improves adoptive T cell therapy

The paper shows that transient EZH2 inhibition with Tazemetostat during T cell expansion maintains stemness and improves adoptive T cell therapy outcomes in a murine model.

Proteomic discovery of chemical probes that perturb protein complexes in human cells

This study develops a proteomic strategy to identify chemical probes that perturb protein complexes in human cells by analyzing electrophilic compounds' effects on protein interactions.

Chemoproteomics-guided Development of SLC15A4 Inhibitors with Anti-inflammatory Activity

The paper develops first-in-class SLC15A4 inhibitors that suppress endosomal TLR and NOD signaling in immune cells and show anti-inflammatory effects in vivo and clinical settings.

Myeloid reprogramming by JAK inhibition enhances checkpoint blockade therapy

Ruxolitinib reshapes myeloid immunity to synergize with checkpoint inhibitors, enhancing anti-tumor T cell activity and improving immunotherapy outcomes.

Enhancing the anti-tumor efficacy of Bispecific T cell engagers via cell surface glycocalyx editing

This study develops BiTE-sialidase fusion proteins that enhance anti-tumor efficacy by desialylating tumor cells, improving T-cell activation and cytolysis in vitro and in vivo.

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-hACE2 transgenic mice

This study shows SARS-CoV-2 infects neurons in the CNS of K18-hACE2 mice, with microglia not restricting viral replication but contributing to inflammation.

An activity-guided map of electrophile-cysteine interactions in primary human immune cells

The paper maps electrophile-sensitive cysteines in primary human T cells and shows how electrophilic compounds affect T cell activation through cysteine modification.