Astrovirus replication is dependent on induction of double membrane vesicles through a PI3K-dependent, LC3-independent pathway
T. Bub, V. Hargest, S. Tan, M. Smith, A. Vazquez-Pagan, T. Flerlage, P. H. Brigleb, V. A. Meliopoulos, B. D. Lindenbach, V. Cortez, J. C. Crawford, S. Schultz-Cherry
This study shows astrovirus replication depends on PI3K-dependent, LC3-independent DMV formation, suggesting PI3K as a therapeutic target for viral infections.
bioRxiv · Apr 11, 2023 · PreprintMicrobiology