S. Schultz-Cherry

Maternal immunization with distinct influenza vaccine platforms elicits unique antibody profiles that impact the protection of offspring

This study compares antibody profiles from maternal influenza vaccines in mice, showing LAIV and rHA provide better offspring protection than TIV.

Diet-induced obesity impacts influenza disease severity and transmission dynamics in ferrets

This study shows diet-induced obesity in ferrets increases influenza disease severity and transmission due to altered lung microenvironment and reduced antiviral responses.

The beta 6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection

This study shows that beta 6 integrin suppresses TLR7-mediated epithelial immunity during influenza A virus infection by promoting autophagy and altering TLR7 trafficking.

Utility of nasal swabs for assessing mucosal immune responses towards SARS-CoV-2

This study shows nasal swabs can assess mucosal immune responses to SARS-CoV-2, revealing distinct cytokine and antibody profiles compared to systemic responses.

Host obesity impacts genetic variation in influenza A viral populations

This study investigates how host obesity affects genetic variation in influenza A virus populations using a ferret model, finding enhanced positive selection and host-specific mutations in obese hosts.

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

This study identifies the role of G3BP1-N interaction in SARS-CoV-2 replication by showing that disrupting this interaction reduces viral replication and pathogenesis.

Astrovirus replication is dependent on induction of double membrane vesicles through a PI3K-dependent, LC3-independent pathway

This study shows astrovirus replication depends on PI3K-dependent, LC3-independent DMV formation, suggesting PI3K as a therapeutic target for viral infections.

Integrated Drivers of Basal and Acute Immunity in Diverse Human Populations

The paper examines factors influencing immunity across diverse populations, finding ancestry and age significantly affect immune responses and disease severity.

Improved metabolic syndrome and timing of weight loss is crucial for influenza vaccine-induced immunity in obese mice

This study shows pre-vaccination weight loss improves influenza vaccine efficacy in obese mice, while post-vaccination weight loss does not.

Reduced inflammatory response and promoted multiciliated cell differentiation in mice protected by defective interfering influenza virus

This study shows that defective interfering influenza virus protects mice from viral infection by reducing inflammation and promoting multiciliated cell differentiation, independent of type I and III IFN signaling.

Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks

This study tracks influenza A virus diversity in ferrets, showing compartmentalized replication and stochastic bottlenecks shaping genetic diversity within lung lobes.

Astrovirus Disrupts Intestinal Barrier Function by Activating Epithelial-Mesenchymal Transition

This study shows human astrovirus infection induces epithelial-mesenchymal transition, disrupting intestinal barrier function through gene upregulation and loss of cell-cell contacts.

Optimized Quantification of Intrahost Viral Diversity in SARS-CoV-2 and Influenza Virus Sequence Data

This study evaluates variant calling tools for detecting minority variants in viral sequencing data and provides guidance for accurate quantification of intrahost viral diversity.

Efficacy of oseltamivir treatment in influenza virus infected obese mice

This study shows oseltamivir treatment does not improve viral clearance in obese mice and may increase viral genetic diversity and drug resistance.

Neuroblastoma formation requires unconventional CD4 T cells and myeloid amino acid metabolism

This study identifies unconventional CD4 T cells and myeloid amino acid metabolism as critical for neuroblastoma formation using a mouse model and spatial transcriptomics.

Coinfection of Streptococcus pneumoniae reduces airborne transmission of influenza virus

This study shows that coinfection with Streptococcus pneumoniae reduces airborne transmission of influenza virus by decreasing viral shedding in the upper respiratory tract of ferrets.

The effects of modified sialic acids on mucus and erythrocytes on influenza A virus HA and NA functions

This study examines how modified sialic acids in mucus and erythrocytes affect influenza A virus HA and NA functions, finding that these modifications inhibit viral binding and cleavage.

Astrovirus Replication Is Inhibited by Nitazoxanide In Vitro and In Vivo

This study shows that nitazoxanide inhibits astrovirus replication in vitro and reduces viral shedding and diarrhea in vivo.

HA stability regulates H1N1 influenza virus replication and pathogenicity in mice by modulating type I interferon responses in dendritic cells

This paper shows that a destabilizing HA mutation in H1N1 influenza virus reduces replication and pathogenicity in mice by enhancing type I interferon responses in dendritic cells.