Author

P. L. Yang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:virus· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:structural biology· 1

Frequent Co-Authors

N. S. Gray· 2 shared A. Chakravarty· 1 shared A. Johnson· 1 shared A. Nguyen· 1 shared A. Ploss· 1 shared B. D. Lindenbach· 1 shared E. S. Fischer· 1 shared F. Douam· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

N. S. Gray

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

Z. Li, H.-Y. Liu, Z. He, A. Chakravarty, R. P. Golden, Z. Jiang, I. You, H. Yue, K. A. Donovan, G. Du, J. Che, J. Tse, I. Che, W. Lu, E. S. Fischer, , P. L. Yang

This study develops small molecule degraders of the dengue virus envelope protein, demonstrating their ability to induce proteosome-mediated degradation and providing a foundation for antiviral drug development.

Advanced Science · Aug 15, 2024Peer-reviewedBiochemistry

A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating

H. N. Ramanathan, S. Zhang, F. Douam, J. Chang, P. L. Yang, A. Ploss, B. D. Lindenbach

This study identifies VCP/p97 as essential for flavivirus nucleocapsid disassembly using a YFV entry reporter system.

bioRxiv · Oct 22, 2019Microbiology

How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion

L. H. Chao, J. Jang, A. Johnson, A. Nguyen, N. S. Gray, P. L. Yang, S. C. Harrison

The paper studies how small-molecule inhibitors block dengue virus membrane fusion by targeting the envelope protein's conformational change, showing that ~15 bound molecules per particle prevent fusion.

bioRxiv · Jul 9, 2018Biophysics