Author

B. E. Johnson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Assay:bulk RNA-seq· 3 Research Focus:clustering· 3 Assay:spatial transcriptomics· 3

Frequent Co-Authors

A. L. Creason· 2 shared A. Rotem· 2 shared E. Demir· 2 shared G. B. Mills· 2 shared H. S. Feiler· 2 shared I. Wakiro· 2 shared J. Goecks· 2 shared J. W. Gray· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

A. L. Creason

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Author profile →

6 papers

Recent·Most cited

Longitudinal and multimodal auditing of tumor adaptation to CDK4/6 inhibitors in HR+ metastatic breast cancers

A. L. Creason, J. Egger, C. Watson, S. Sivagnanam, K. Chin, K. MacPherson, J.-R. Lin, Y.-A. Chen, B. E. Johnson, H. S. Feiler, D. Galipeau, N. E. Navin, E. Demir, Y. H. Chang, C. L. Corless, , J. Goecks

This study creates a multimodal tumor atlas to analyze how metastatic HR+ breast cancers adapt to CDK4/6 inhibitors, revealing mechanisms like mTORC1 activation and immune microenvironment changes.

bioRxiv · Sep 27, 2023 · PreprintCancer Biology

A cellular and spatial atlas of TP53-associated tissue remodeling in lung adenocarcinoma

W. Zhao, B. Kepecs, N. R. Mahadevan, A. Segerstolpe, J. L. Weirather, N. R. Besson, B. Giotti, B. Y. Soong, C. Li, S. Vigneau, M. Slyper, I. Wakiro, J. Jane-Valbuena, O. Ashenberg, A. Rotem, , A. M. Tsankov

This study constructs a multi-omic atlas of TP53-mutant lung adenocarcinoma tumors, revealing altered cellular identity, gene expression programs, and spatial interactions in the tumor microenvironment.

bioRxiv · Jun 28, 2023 · PreprintCancer Biology

Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections

P. G. Schupp, S. J. Shelton, D. J. Brody, R. Eliscu, B. E. Johnson, T. Mazor, K. W. Kelley, M. B. Potts, M. W. McDermott, E. J. Huang, D. A. Lim, R. O. Pieper, M. S. Berger, J. F. Costello, J. J. Phillips, M. C. Oldham

This study develops MOMA, a multiomic and multiscale analysis method to deconstruct intratumoral heterogeneity in IDH-mutant astrocytomas, revealing molecular features and spatial distributions of malignant clones.

bioRxiv · Jun 21, 2023Cancer Biology

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

M. S. Taylor, W. Connie, P. C. Fridy, S. J. Zhang, Y. Senussi, J. C. Wolters, W.-C. Cheng, J. Heaps, B. D. Miller, K. Mori, L. Cohen, H. Jiang, K. R. Molloy, B. L. Norden, B. T. Chait, , O. H. Yilmaz

This study develops ultrasensitive assays to detect ORF1p in plasma, showing its potential as a multi-cancer biomarker for early detection and monitoring.

bioRxiv · Jan 25, 2023 · PreprintCancer Biology

An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer

B. E. Johnson, A. L. Creason, J. M. Stommel, J. M. Keck, S. Parmar, C. B. Betts, A. Blucher, C. Boniface, E. Bucher, E. A. Burlingame, T. Camp, K. Chin, J. Eng, J. Estabrook, H. S. Feiler, , J. W. Gray

This paper presents an OMS Atlas from serial biopsies of a metastatic breast cancer patient, linking clinical data to multi-omic and spatial profiles to study therapy-associated heterogeneity and resistance mechanisms.

bioRxiv · Dec 3, 2020Cancer Biology

The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer

S. Raghavan, P. S. Winter, A. W. Navia, H. L. Williams, A. DenAdel, R. L. Kalekar, J. Galvez-Reyes, K. E. Lowder, N. Mulugeta, M. S. Raghavan, A. A. Borah, K. S. Kapner, S. A. Vayrynen, A. Dias Costa, R. W. S. Ng, , A. K. Shalek

This study identifies a transitional cancer cell state in metastatic pancreatic cancer and shows that tumor microenvironment signals drive transcriptional plasticity and subtype transitions.

bioRxiv · Aug 25, 2020 · PreprintCancer Biology