This paper develops a novel mouse model of TNBC by combining MYC amplification and PTEN deletion, showing it recapitulates human TNBC heterogeneity through omic analyses.

bioRxiv · Oct 7, 2022 · PreprintCancer Biology

Relevance of Circulating Hybrid Cells as a Non-Invasive Biomarker for Myriad Solid Tumors

M. S. Dietz, T. L. Sutton, B. S. Walker, C. E. Gast, L. Zarour, S. K. Sengupta, J. R. Swain, J. Eng, M. Parappilly, K. Limbach, A. Sattler, E. Burlingame, Y. Chin, A. Gower, J. L. Montoya Mira, , M. H. Wong

This study identifies circulating hybrid cells (CHCs) as a novel biomarker for metastatic solid tumors, showing they outnumber CTCs and exhibit tumor-initiating properties across multiple cancer types.

bioRxiv · Mar 11, 2021 · PreprintCancer Biology

An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer

B. E. Johnson, A. L. Creason, J. M. Stommel, J. M. Keck, S. Parmar, C. B. Betts, A. Blucher, C. Boniface, E. Bucher, E. A. Burlingame, T. Camp, K. Chin, J. Eng, J. Estabrook, H. S. Feiler, , J. W. Gray

This paper presents an OMS Atlas from serial biopsies of a metastatic breast cancer patient, linking clinical data to multi-omic and spatial profiles to study therapy-associated heterogeneity and resistance mechanisms.

bioRxiv · Dec 3, 2020Cancer Biology

Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes

K. E. Ware, S. Gupta, J. Eng, G. Kemeny, B. J. Puviindran, W.-C. Foo, L. A. Crawford, R. G. Almquist, D. Runyambo, B. C. Thomas, M. U. Sheth, A. Agarwal, M. Pierobon, E. F. Petricoin, D. L. Corcoran, , J. Somarelli

This study identifies p38/MAPK pathway activation as a convergent mechanism driving survival, immune evasion, and metastasis in hormone-resistant prostate cancer.

bioRxiv · Apr 22, 2020 · PreprintCancer Biology