K. Chin

Longitudinal and multimodal auditing of tumor adaptation to CDK4/6 inhibitors in HR+ metastatic breast cancers

This study creates a multimodal tumor atlas to analyze how metastatic HR+ breast cancers adapt to CDK4/6 inhibitors, revealing mechanisms like mTORC1 activation and immune microenvironment changes.

Robust biomarker discovery through multiplatform multiplex image analysis of breast cancer clinical cohorts

The paper identifies prognostic spatial biomarkers in breast cancer by analyzing multiple clinical cohorts using three multiplex imaging technologies.

A Novel Mouse Model that Recapitulates the Heterogeneity of Human Triple Negative Breast Cancer

This paper develops a novel mouse model of TNBC by combining MYC amplification and PTEN deletion, showing it recapitulates human TNBC heterogeneity through omic analyses.

A framework for multiplex imaging optimization and reproducible analysis

The paper introduces a framework and software for optimizing and reproducibly analyzing multiplex imaging data, focusing on cyclic immunofluorescence.

Cyclic Nucleotide-Gated Ion Channel 2 modulates auxin homeostasis and signaling

This study shows that CNGC2 modulates auxin homeostasis and signaling by influencing auxin biosynthesis and Ca2+ signaling in Arabidopsis.

Relevance of Circulating Hybrid Cells as a Non-Invasive Biomarker for Myriad Solid Tumors

This study identifies circulating hybrid cells (CHCs) as a novel biomarker for metastatic solid tumors, showing they outnumber CTCs and exhibit tumor-initiating properties across multiple cancer types.

An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer

This paper presents an OMS Atlas from serial biopsies of a metastatic breast cancer patient, linking clinical data to multi-omic and spatial profiles to study therapy-associated heterogeneity and resistance mechanisms.

Predictive modeling of virus inactivation by UV

The paper develops predictive models for UV254 virus inactivation rates using existing data and genome attributes, achieving accurate predictions for untested viruses.

Comparison of ultrafiltration and iron chloride flocculation in the preparation of aquatic viromes from contrasting sample types

This study compares ultrafiltration and iron chloride flocculation for virome preparation across different aquatic matrices, finding ultrafiltration more effective for DNA concentration and quality.

HER2 Cancer Protrusion Growth Signaling Regulated by Unhindered, Localized Filopodial Dynamics

This study investigates how HER2 dynamics in filopodia regulate protrusion growth and signaling in breast cancer cells, revealing distinct motion patterns and functional roles in protrusion-based signaling.