Author

B. Gigant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Akhmanova· 1 shared A. Urvoas· 1 shared C. van Hoorn· 1 shared E. Muto· 1 shared F. E. Ogunmolu· 1 shared F. Herzog· 1 shared H. Imai· 1 shared H. Shigematsu· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCell Biology

A. Akhmanova

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3 papers

Recent·Most cited

Microtubule plus-end regulation by centriolar cap proteins

F. E. Ogunmolu, S. Moradi, V. A. Volkov, C. van Hoorn, J. Wu, N. Andrea, S. Hua, K. Jiang, I. A. Vakonakis, M. Potocnjak, F. Herzog, B. Gigant, N. Gudimchuk, K. E. Stecker, M. Dogterom, , A. Akhmanova

The paper investigates how CP110 and CEP97 regulate microtubule plus-end dynamics and centriole biogenesis through direct interactions and synergistic effects.

bioRxiv · Dec 29, 2021 · PreprintCell Biology

Structural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors

V. Campanacci, A. Urvoas, L. Ammar Khodja, M. Aumont-Nicaise, M. Noiray, S. Lachkar, P. A. Curmi, P. Minard, B. Gigant

The paper reports structures of tubulin bound to CPAP's PN2-3 domain and shows structural convergence with vinca domain inhibitors.

bioRxiv · Oct 19, 2021Biochemistry

GTP-dependent formation of straight oligomers leads to nucleation of microtubules

R. Ayukawa, S. Iwata, H. Imai, S. Kamimura, M. Hayashi, K. X. Ngo, I. Minoura, S. Uchimura, T. Makino, M. Shirouzu, H. Shigematsu, K. Sekimoto, B. Gigant, E. Muto

The paper shows that GTP-dependent formation of straight oligomers is essential for microtubule nucleation, with a mutation increasing straight oligomers and accelerating nucleation.

Journal of Cell Biology · Feb 5, 2021Peer-reviewedBiophysics