M. Hayashi

Flow zoometry of Drosophila

This paper introduces flow zoometry, a high-throughput screening method for Drosophila, enabling rapid, automated, and high-resolution analysis of whole animals.

Nonadjacent Dependencies and Syntactic Structure of Chimpanzee Action During a Natural Tool-Use Task

This study examines nonadjacent dependencies in chimpanzee tool-use sequences, finding evidence of hierarchical structuring similar to human language.

Characterization of transcriptional heterogeneity and novel therapeutic targets using single cell RNA-sequencing of primary and circulating Ewing sarcoma cells.

This study uses single-cell RNA-sequencing to analyze transcriptional heterogeneity in Ewing sarcoma and identifies TSPAN8 as a novel therapeutic target.

Immunosuppressive tumor microenvironment of osteosarcoma

This study identifies immunosuppressive mechanisms in osteosarcoma using single-cell and spatial transcriptomics, revealing interactions between MDSCs, T-cells, and tumor cells that promote an immunosuppressive microenvironment.

Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth

This study identifies a LKB1-LIF signaling axis in tumors that promotes immune evasion by reprogramming myeloid cells, and shows that inhibiting LIF signaling reduces tumor growth.

Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer

This study shows that DRP-104, a glutamine antagonist, suppresses KEAP1 mutant lung tumor growth and enhances response to checkpoint blockade by inhibiting glutamine metabolism and improving T cell function.

Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist

This study identifies KSI-6666 as a pseudoirreversible S1PR1 antagonist that suppresses inflammation through interaction with a methionine residue.

Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors.

The paper shows that inhibiting HDACs selectively targets NRF2-activated lung adenocarcinoma by altering chromatin and metabolic pathways.

SEN1 is responsible for molybdate transport into nodule symbiosomes for nitrogen fixation in Lotus japonicus

The paper identifies SEN1 as a molybdate transporter responsible for exporting molybdate from host plant cytosol to symbiosomes for nitrogen fixation in Lotus japonicus.

A novel cis-element enabled bacterial uptake by plant cells

The paper identifies a cis-regulatory element, PACE, critical for bacterial uptake in plant cells through its role in nodule formation and infection thread development.

Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota

This study determines the crystal structures of OxlT, an oxalate transporter, and reveals its mechanism for selective oxalate uptake and exclusion of other carboxylates.

GTP-dependent formation of straight oligomers leads to nucleation of microtubules

The paper shows that GTP-dependent formation of straight oligomers is essential for microtubule nucleation, with a mutation increasing straight oligomers and accelerating nucleation.

OsNLP4 is required for nitrate assimilation gene expressions and nitrate-dependent growth in rice

The study identifies OsNLP4 as essential for nitrate assimilation gene expression and nitrate-dependent growth in rice.

Multiple kinesin-14 family members drive microtubule minus-end-directed transport in plant cells

The paper identifies two kinesin-14 family members in plants that drive minus-end-directed transport of membranous cargoes, compensating for the absence of dynein.